Low birth weight as the result of placental insufficiency increases the risk of hypertension in young adults; however, the vascular mechanisms involved are unclear. We tested the hypothesis that intrauterine fetal growth restriction caused by placental insufficiency results in low-birth-weight offspring with impaired endothelium-dependent vascular relaxation, enhanced vasoconstriction, and hype...

Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K(+) channels. Because contractility of uterine muscle is regulated by extracellular pH and humoral factors, K(+) conductance could be connected to factors regulating uterine contractility during pregnancy. Here, we showed that TASK-2 inhibit...

The objective of this study was to evaluate diastolic parameters and left ventricular geometry in gestational hypertension. Twenty-one consecutive pregnant women with gestational hypertension and 21 normotensive women matched for age and gestational age were enrolled in the third trimester of gestation. Echocardiographic and uterine color Doppler evaluations were performed. Systolic, diastolic,...

BACKGROUND AND OBJECTIVES Ex utero intrapartum treatment (EXIT) is a procedure performed during Cesarean section with preservation of fetal-placental circulation, which allows the safe handling of fetal airways with risk of airways obstruction. This report aimed at describing a case of anesthesia for EXIT in a fetus with cervical cystic hygroma. CASE REPORT Female patient, 22 years old, 37 we...

a rare case of non-puerperal uterine inversion caused by a large fundal leiomyoma in a 39-year nulliparous, infertile woman resulting in intractable hemorrhage was reported after a myomectomy. attempts to reduce the inversion vaginally by transecting the anterior and posterior cervix were unsuccessful and a laparotomy was performed. the inversion was not successfully corrected and hysterectomy ...

Epidemiological studies have shown increased incidence of hypertension and coronary artery disease in growth-restricted fetuses during their adult life. A novel animal model was used to test the hypothesis regarding the role of an abnormal uterine environment in fetal programming of adult vascular dysfunction. Mice lacking a functional endothelial nitric oxide synthase (NOS3-/-KO, where KO is k...

Rosenfeld CR, Liu X, DeSpain K. Pregnancy modifies the large conductance Ca -activated K channel and cGMP-dependent signaling pathway in uterine vascular smooth muscle. Am J Physiol Heart Circ Physiol 296: H1878–H1887, 2009; doi:10.1152/ajpheart.01185.2008.— Regulation of uteroplacental blood flow (UPBF) during pregnancy remains unclear. Large conductance, Ca -activated K channels (BKCa), consi...

to investigate uterine and serum copper (cu) and zinc (zn) concentrations variation duringthe bovine estrus cycle , 232 blood and genital tract samples were collected from the abattoir inurmia. the phase of the estrous cycle was determined by the examination of the ovaries and theuterine tonicity. of the 46 samples selected for use in the study, 13 were pro-estrus, 10 estrus, 8metestrus, and 15...