We praise the article by Mokhtari-Zaer et al. (2015) published in the Avicenna Journal of Phytomedicine on the effects of saffron on smooth muscle activity (Mokhtari-Zaer et al., 2015). It was a well-designed and interesting study on the therapeutic properties of Crocus sativus which is a precious plant cultivated in our country. We do believe that along with all other medicinal effects, saffro...

background: abnormal uterine bleeding is a common presentation of uterine abnormalities among premenopausal and postmenopausal women. objective: to evaluate and compare the diagnostic accuracy of saline contrast sonohysterography and hysteroscopy for detecting the cause of abnormal uterine bleeding. materials and methods: a total of 65 women with abnormal uterine bleeding were enrolled in this ...

Pregnancy is associated with a significant increase in uterine blood flow which contributes to optimal fetal development. Although neuropeptide Y (NPY) is considered to be an important regulator of uterine blood flow, it is not known whether: (i) products from the vascular endothelium modulate NPY action in the uterine artery; (ii) pregnancy changes the responsiveness of the uterine artery to N...

The objectives of this study were to investigate the effects KISS1 94-121 fragment on contractility non-pregnant and pregnant rat uteri, determine uterine myometrial expressions Kiss1r. Uterine muscle strips obtained from Sprague-Dawley rats in oestrous phase gestational days 5, 15, 18, 20 or 22. vitro measurements carried out an isolated organ bath presence 94-121. Experiments with 5-day tissu...

Background: Uterine fibroids or uterine myomas are benign tumors cell myometrial smooth muscle surrounded by a pseudocapsule. occur in reproductive age women and will slowly disappear at menopause. the second most common problem experienced Indonesia after cervical cancer. The world incidence rate of is 20-35%, while ranges from 2.4% to 11.7%. study was conducted know related factors with incid...

Pregnancy is associated with a significant decrease in uterine vascular tone and an increase in uterine blood flow. The present study tested the hypothesis that estrogen and progesterone differentially regulate the extracellular signal-regulated kinase (ERK)1/2 and protein kinase C (PKC) signaling pathways in vascular smooth muscle, resulting in a decrease in uterine vascular myogenic tone in p...

The uterus and heart share the important physiological feature whereby contractile activation of the muscle tissue is regulated by the generation of periodic, spontaneous electrical action potentials (APs). Preterm birth arising from premature uterine contractions is a major complication of pregnancy and there remains a need to pursue avenues of research that facilitate the use of drugs, tocoly...

Organized uterine contractions, including those necessary for parturition, are dependent on calcium entry through voltage-gated calcium channels in myometrial smooth muscle cells. Recent evidence suggests that small-conductance Ca(2+)-activated potassium channels (K(Ca)2), specifically isoforms K(Ca)2.2 and 2.3, may control these contractions through negative feedback regulation of Ca(2+) entry...

Uterine smooth muscle tumors range from benign leiomyomata to low- and high-grade leiomyosarcomas. A leiomyosarcoma is a rare malignant smooth muscle tumor that infrequently metastasizes to the bone. In fact, initial presentation or recurrence as osseous metastases is extremely uncommon in patients with a history of leiomyosarcoma. On imaging, these bone lesions generally appear as lytic foci. ...