The paper presents a new framework of analyzing the product itself to infer about future market demands. This framework consists of past regularities that were identified to underlie the emergence of successful new products. By identifying templates of innovation an innovator may be able to predict the future product even before the market signals the needs or when the market information is not...

The computer system PROSPECT for the protein fold recognition using the threading method is described and evaluated in this article. For a given target protein sequence and a template structure, PROSPECT guarantees to find a globally optimal threading alignment between the two. The scoring function for a threading alignment employed in PROSPECT consists of four additive terms: i) a mutation ter...

PURPOSE: Creating patient-specific replacement organs promises to address shortcomings in transplantation, including the need for immunosuppression and limited donor supply. A major roadblock to tissue engineering is the inability to synthesize an intact circulatory system de novo. Thus, tissues produced by the current paradigm of seeding cellular scaffolds are rendered critically ischemic by t...

This paper covers the processes of designing the system architecture and the authoring interface for Pachyderm 2.0, as well as some of the fundamental conceptual strategies that enabled the development of the software. It describes the architecture of the underlying frameworks, applications, and content templates. Areas for potential collaboration and development are identified.

PURPOSE: Creating patient-specific replacement organs promises to address shortcomings in transplantation, including the need for immunosuppression and limited donor supply. A major roadblock to tissue engineering is the inability to synthesize an intact circulatory system de novo. Thus, tissues produced by the current paradigm of seeding cellular scaffolds are rendered critically ischemic by t...

The first step in mining activities is rock excavation in both mine development and production. Constant pressure for cost reduction and creating an improved/safe work environment for personnel has naturally resulted in increased use of mechanical excavation systems in many mining operations. Also, mechanical excavation and mining is more compatible with automation, meaning possibility of reduc...

introduction: the use of laser for cavity preparation or conditioning of dentin and enamel surfaces as an alternative for dental tissue acid-etch have increased in recent years. the aim of this in vitro study was to compare microleakage at enamel-composite and dentincomposite interfaces following erbium-doped yttrium aluminum garnet(er:yag) laser conditioning or acid-etching of enamel and denti...

Abstract Objectives Comparing time use patterns and self-efficacy in two groups of mothers including mothers of children with CP and mothers of children with typical development is the main objective of this study. Method This study was carried out in 2017 in Arak, on 200 mothers. Multiple sources of evaluation were used including Mothers' Time Use Questionnaire and Sherer General Self-eff...