BACKGROUND A study was undertaken to determine the relation between urinary cadmium levels and lung function in a nationally representative cohort of current, former, and never smokers in the US. Urinary cadmium levels reflect the total body burden of cadmium. METHODS The following data from the Third National Health and Nutrition Examination Survey were analysed: urinary cadmium (adjusted fo...

Background: A study was undertaken to determine the relation between urinary cadmium levels and lung function in a nationally representative cohort of current, former, and never smokers in the US. Urinary cadmium levels reflect the total body burden of cadmium. Methods: The following data from the Third National Health and Nutrition Examination Survey were analysed: urinary cadmium (adjusted fo...

asthma environmental triggers play important roles in severity of disease. passive smoking could exacerbate asthma symptoms and enhance the decrease in lung function. cotinine levels could be a reflection of passive exposure to the cigarette both in adults and pediatrics. the aim of this study was to determine degree of association of asthma severity and cotinine level as a marker of passive sm...

BACKGROUND Identifying sources of variation in the nicotine and nitrosamine metabolic inactivation pathways is important to understanding the relationship between smoking and cancer risk. Numerous UGT1A and UGT2B enzymes are implicated in nicotine and nitrosamine metabolism in vitro; however, little is known about their roles in vivo. METHODS Within UGT1A1, UGT1A4, UGT1A9, UGT2B7, UGT2B10, an...

The association between the distribution characteristics of CYP2A6 catalytic activities toward nicotine and coumarin, and the frequency distribution of CYP2A6 variant alleles reported was estimated in 120 healthy Thais. The distributions of the subjects as classified by the amounts of 7-hydroxycoumarin (7-OHC) excreted in the urine and by cotinine/nicotine ratio in the plasma were clearly bimod...