Hyperlipidic diets limit glucose oxidation and favor amino acid preservation, hampering the elimination of excess dietary nitrogen and the catabolic utilization of amino acids. We analyzed whether reduced urea excretion was a consequence of higher NO x ; (nitrite, nitrate, and other derivatives) availability caused by increased nitric oxide production in metabolic syndrome. Rats fed a cafeteria...

We studied the effects of supplementing N as distillers dried grains with solubles (DDGS) or urea to steers consuming corn-based diets. Six ruminally and duodenally cannulated steers (244 kg) were used in 2 concurrent 3 x 3 Latin squares and fed 1 of 3 corn-based diets: control (10.2% CP), urea (13.3% CP), or DDGS (14.9% CP). Periods were 14 d, with 9 d for adaptation and 5 d for collection of ...

OBJECTIVE Ammonia detoxification is essential for physiological well-being, and the urea cycle in liver plays a predominant role in ammonia disposal. Nobiletin (NOB), a natural dietary flavonoid, is known to exhibit various physiological efficacies. In the current study, we investigated a potential role of NOB in ammonia control and the underlying cellular mechanism. MATERIALS/METHODS C57BL/6...

In plants, urea derives either from root uptake or protein degradation. Although large quantities of urea are released during senescence, urea is mainly seen as a short-lived nitrogen (N) catabolite serving urease-mediated hydrolysis to ammonium. Here, we investigated the roles of DUR3 and of urea in N remobilization. During natural leaf senescence urea concentrations and DUR3 transcript levels...

1. Diflubenzuron, [1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl) urea] is an acyl urea derivative for use in the treatment of sea lice (Lepeophtheirus salmonis) infestations in Atlantic salmon. Diflubenzuron is admixed as a 90% pre-concentrate in pelleted diet at a final concentration of 0.6 g diflubenzuron/kg. The intended oral dosage is 3 mg diflubenzuron/kg bw/day during 14 consecutive days. Th...

Neonatal-onset propionic acidemia is the most common form of disorder. A 9-days old new born admitted to our hospital with lethargy suggested urea cycle defect at first look due to lack of metabolic acidosis, normal ketone and anion gap in laboratory evaluations. The case mimicking urea cycle defect, which was diagnosed as neonatal-onset propionic acidemia by specific tests, was presented becau...

1. Urea retention, in the sense of a relatively increased concentration in the blood, is the result of increased resistance to the excretion of urea through the kidneys. 2. The relatively increased concentration of urea in the blood overcomes the increased resistance to excretion, and the organism is thereby maintained in nitrogenous equilibrium. 3. The laws formulated by Ambard for the excreti...

Metabolites derived from dietary choline and L-carnitine, such as trimethylamine N-oxide and betaine, have recently been identified as novel risk factors for atherosclerosis in mice and humans. We sought to identify genetic factors associated with plasma betaine levels and determine their effect on risk of coronary artery disease (CAD). A two-stage genome-wide association study (GWAS) identifie...

The ornithine + citrulline -+ arginine cycle of urea synthesis originally proposed by Krebs and Henseleit (1) has had increasing experimental support (2-10). The position of citrulline in the cycle, however, has been questioned (11). With the advent of the successful separation of the two over-all enzymatic steps, ornithine -+ citrulline and citrulline -+ arginine (lo), from the intact cellular...