OBJECTIVES Exercise on referral schemes (ERS) are widely commissioned in the UK but there is little evidence of their association with physical activity levels. We sought to assess the Northumberland exercise on referral scheme in terms of increased levels of physical activity and identify predictors of engagement. DESIGN A naturalistic observational study. SETTING 9 local authority leisure...

PURPOSE The purpose is to investigate whether STI571, through platelet-derived growth factor receptor inhibition, enhances the therapeutic response to the chemotherapeutic drug epothilone B (EPO906) and, if so, to analyze the mechanism(s) underlying the effect. EXPERIMENTAL DESIGN SCID mice with s.c. human anaplastic thyroid carcinomas were treated with different doses of EPO906 alone or in c...

Improved phenotyping tools for simultaneously characterizing maize (Zea mays L.) genotypes with superior grain yield (GY) and N use effi ciency (NUE) would be benefi cial for breeding progress. Possible phenotypic predictors of the crowding intensity and N availability effects on maize plant N uptake, GY, and NUE were evaluated for different genotypes in two environments. Our objectives were to...

OBJECTIVE To determine the usefulness of 99mtechnetium (99mTc) immunoglobulin scintigraphy (99mTc IgG) in rheumatoid arthritis (RA) and in other arthritides. METHODS Scintigraphic scores were compared with the Ritchie index and biochemical variables of disease activity. RESULTS In RA, scintigraphic scores were reproducible and seemed to perform better than clinical scores. Moreover, the sco...

By EFSTRATIOS S. KURTIDES, WALTER A. RAMBACH AND HOWARD L. ALT T HE INCORPORATION of tritiated thymidine by the rat spleen is an accurate and reliable index of erythropoiesis under certain well-defined experimental conditions.1 Since tritiated thymidine uptake by various tissues reflects DNA synthesis, and therefore proliferative activity, changes in the latter will be reflected by parallel cha...

The biodistribution of 227Th-EDTMP and retention of its daughter nuclide 223Ra were examined. 227Th-EDTMP was found to show high uptake and long-term retention in bone. The clearance of 227Th-EDTMP from blood and soft tissues was rapid and the femur-to-tissue uptake ratios reached more than 100 within 30 min for all tissues except the kidney. Seven and 14 days after injection of 227Th-EDTMP, th...

In this paper we applied our previously developed assessment framework to the data collected from an internet security readiness survey targeted at households. We used the assessment framework to compute an Internet Security Readiness index for each household, which was in turn derived from Internet Security Readiness capital, skill, and actual uptake/use of infrastructure indices. We then exam...

ABSTRACT Zinc is employed as a supplement; however, zinc-related nephropathy is not generally known. In this study, we investigatecl zinc-induced renal cell iajury using a pig kidney-derived cultured renal epithelial cell line, LLC-PKI, with proximal kidney tubule-like features, and examined the involvement of free radicals and extracellular signal-regu]ated kinase (ERK) in the cell injury. The...

We report a method for real-time monitoring of vapor uptake by simultaneous detection of the refractive index, n, and thickness, d, of thin transparent films with a precision of δn=10(-4) and δd<100 nm. The setup combines total internal reflection (Abbé) refractometry with an interferometric imaging method. A fast Fourier transform and phase fitting method is applied for accurate and independen...

RESEARCH DESIGNANDMETHODSdThe study involved 275 outpatients at Kurume University, Japan (189males and 86 females; mean age 61.26 8.8 years) who underwent complete history and physical examinations and determinations of blood chemistry and anthropometric variables, includingAGEs. SerumAGE levelwas examinedby enzyme-linked immunosorbent assay. Vascular [F]fluorodeoxyglucose (FDG) uptake, an inde...