Ubiquitination is a post-translational modification that plays a role in several cellular processes including cell cycle progression, cell proliferation, DNA replication and apoptosis. Ubiquitin-mediated signaling is frequently altered in cancer cells. Several tumor suppressors and oncogenes interact with enzymes of the ubiquitin-proteasome pathway that function in ubiquitin conjugation and dec...

The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways, where abnormal UPS function has been observed in cancer and neurological diseases. Many neurodegenerative diseases share a common pathological feature, namely intracellular ubiquitin-positive inclusions formed by aggregate-prone neurotoxic proteins. This suggests that dysfunction of the UPS in neurodegenerat...

Since proteins play crucial roles in all biological processes, the finely tuned equilibrium between their synthesis and degradation regulates cellular homeostasis. Controlling the quality of proteome informational content is essential for cell survival and function. After initial synthesis, membrane and secretory proteins are modified, folded, and assembled in the endoplasmic reticulum, whereas...

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Underground pedestrian systems (UPS) have been developed worldwide especially in the central areas of mega cities. They are integrated with subway systems, underground shopping streets and malls, and the basement of department stores in various forms and integrated with commerce, transport, retailing and public usage in urban functions. In cities with severe weather conditions such as Toronto a...

Plyometric research in the upper extremity is limited, with the effects of open-chain plyometric exercises being studied most. Kinematic and ground reaction force data concerning closed-chain upper extremity plyometrics has yet to be examined. Twenty-one recreationally active male subjects performed four variations of plyometric push-ups in a counterbalanced order. These included box drop push-...

Aggregation-prone proteins have been suggested to overwhelm and impair the ubiquitin/proteasome system (UPS) in polyglutamine (polyQ) disorders, such as Huntington's disease (HD). Overexpression of an N-terminal fragment of mutant huntingtin (N-mutHtt), an aggregation-prone polyQ protein responsible for HD, obstructs the UPS in cellular models. Furthermore, based on the accumulation of polyubiq...

Undifferentiated pleomorphic sarcoma (UPS) is the most common sarcoma that appears in older patients, usually in the extremities and the retroperitoneum. Other locations are rare. By definition, in UPS, although the malignant cells tend to appear fibroblastic or myofibroblastic, they should not show differentiation towards a more specific line of differentiation. In this sense, we report the ca...

F. Granat, O. Dossin, R. Henrion, M. Pastor, C. Layssol-Lamour, D. Jacques, M. Delverdier, C. Trumel 1: Université de Toulouse, UPS, INP, ENVT, UMS006, Laboratoire Central de Biologie Médicale, F-31076 Toulouse, France 2: INSERM, UMS 006, Laboratoire Central de Biologie Médicale, F-31076 Toulouse, France 3: Université de Toulouse, UPS, INP, ENVT, Internal Medicine, Department of Small Animal Cl...

InterMath participants spend time in workshops exploring technology-rich mathematical investigations and completing write-ups. These write-ups include a written explanation of their problem solving process, screen captures of files that they generated while completing the investigation and links to these files. This paper examines the use of graphical representations in write-ups that included ...