Correspondence to: Professor David C Crossman, Cardiovascular Research Unit, Division of Clinical Sciences (North), Clinical Sciences Centre, Herries Road, Northern General Hospital, Sheffield S5 7AU, UK; d.c.crossman@ sheffield.ac.uk _________________________ M yocardial ischaemia is responsible for angina, unstable angina, and, less commonly, shortness of breath secondary to ischaemic left ve...

In a majority of instances, both unstable angina and acute myocardial infarction occur secondary to plaque disruption and thrombus formation. Although the pathogenetic substrates are similar the clinical presentations are quite different. It is hypothesized in this editorial review that the amount of acute thrombus formation and specifically fibrin deposition is greater in myocardial infarction...

The frequency and type of acute lesions in the four major (right, left main, left anterior descending, left circumflex) epicardial coronary arteries were examined at necropsy in 14 patients with unstable angina pectoris, 21 patients with sudden coronary death and 32 patients with a fatal first acute myocardial infarction. None of the 67 patients had a grossly visible left ventricular scar (heal...

OBJECTIVE Instability of coronary atheroma leads to the onset of acute coronary syndromes including myocardial infarction and death, as well as to the progression of the arteriosclerotic disease. As yet, the underlying factors and mechanisms causing plaque rupture are not completely understood. Since a low content of smooth muscle cells (SMCs) apparently plays a key role, the question points to...

BACKGROUND Unstable angina is a common cause of admission to hospitals. There is conflicting evidence on the need and success of urgent coronary revascularization in such cases. This study was conducted to evaluate the early post-operative morbidity and mortality of Coronary Artery Bypass Grafting (CABG) in patients with unstable angina. METHODS This cross sectional descriptive study was cond...

OBJECTIVE Based on its role in inflammation and matrix degradation, we hypothesized a role for osteoprotegerin (OPG), RANK, and RANK ligand (RANKL) in coronary artery disease. METHODS AND RESULTS We examined the expression of various members of the OPG/RANKL/RANK axis in patients with stable and unstable angina and in the atherosclerotic lesions of apolipoprotein E-deficient (apoE(-/-)) mice....

Objective: To find outthe frequency of cardiogenic shock in patients with ACS Study design: Cross sectional study Methodology:A calculated sample 240 presented acute coronary syndrome confirmed clinically and/or on the basis ECG and cardiac markers was taken. In addition to collecting basic demographic details were inquired about presence risk factors (smoking status, diabetesand hypertension)....

Percutaneous transluminal coronary angioplasty was performed in 25 patients with unstable angina and in a similar group of 25 patients with stable angina. The frequency of single, double, and triple vessel disease was identical in each group. Technical success was achieved in 22 (81%) out of 27 attempts in those with unstable angina and in 14 (52%) out of 27 attempts in those with stable angina...

Recent reports have suggested that cytomegalovirus (CMV) infection may contribute to risk of cardiovascular disease. However, relationship between CMV infection and unstable angina (UA) is controversial and studies about this subject in Iran and even region are lacking. The aim of this study was to determine whether unstable angina is related to seropositivity to chronic cytomegalovirus infecti...

Unstable angina is a critical phase of coronary heart disease with widely variable symptoms and prognosis. A decade ago, a classification of unstable angina based on clinical symptoms was introduced. This system was then validated by prospective clinical studies to correlate with the prognosis and was linked to angiographic and histological findings. It has been used to categorize patients in m...