defects in genes for survival motor neuron (smn) and neural apoptosis inhibitory proteins (naip) have been reported associated with spinal muscular atrophy (sma). among the genetic defects, deletions in exons 7 and 8 of smn and exons 4 and 5 of naip were found to be most significant. in the current study, 35 unrelated sma patients including 9 patients with type i, 6 with type ii, 20 with type i...

the mean and variance of the lagrangian katz family of distribution (lkd), the basiclagrangian katz distribution of type i (lkd-i) and type ii (lkd-ii) are provided in an easy method.the recurrence relation between the non-central, central and factorial moments, and the recurrencerelation between moments and cumulants of lkd, lkd-i and lkd-ii are given. the first fourcumulants of lkd-i and lkd-...

We investigate the effect of a pinned superfluid component on gravitational wave emission rotating neutron star. Pinning vortices to flux-tubes in outer core (where protons are likely form type-II superconductor) is possible mechanism sustain long-lived and non-axisymmetric currents interior, that break axial symmetry unperturbed hydrostatic configuration. consider pinning-induced perturbations...

the aim of this study was to report the endodontic management of right maxillary central incisor having two canals with vertucci canal configuration type iv . internal morphology of root canals is variable and often complex. therefore, to achieve a technically satisfactory endodontic outcome, the clinician must have adequate knowledge of the internal canal morphology and its variations in order...

Two new nano particles of copper (II) and nickel (II) complexes, [Cu(cd5Clsalen)] (1) and [Ni(cd5Clsalen)] (2) with unsymmetrical tetradentate Schiff base ligand cd5Clsalen={methyl-2-[N-[2-(2-hydroxy-5-choloro-2phenyl) methylidynetrilo]ethyl}amino-1-cyclopentenedithiocarboxylate, were synthesized by hydrothermal method. These compounds were characterized by a variety of physic-chemical techniqu...

Introduction: Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and usually fatal lung disease of unknown etiology for which no effective treatments currently exist. In the adults type I and II pneumocytes, forms Components of the alveolar epithelial cells. In this study, we investigated the effect of thalidomide on the alveolar epithelial cells (type I and II pneumocytes) in ...

the maxillary first premolar may present large number of anatomic variations. the clinician should be aware of the configuration of the pulp system. maxillary first premolars usually have two canals. the incidence of three canals in these teeth is quite rare. this case report presents the diagnosis and clinical management of a maxillary first premolar with two distinct canals in the apical thir...

The roles of calmodulin (CaM)-dependent protein kinase II (CaMKII) in the maintenance of basal activity and the reversion of run-down of L-type Ca2+ channels were studied in guinea-pig ventricular myocytes by the patch-clamp technique. In the cell-attached configuration, the Ca2+-channel activity was inhibited to 82% - 26% by 1-10 microM KN-93 and to 92% - 66% by 0.1-1 microM autocamtide-2-rela...

Nickel(II)-xylylbicyclam is a potent anti-HIV agent and binds strongly to the CXCR4 co-receptor. We have investigated configurational equilibria of Ni(II)-cyclam derivatives, since these are important for receptor recognition. Crystallographic studies show that both trans and cis configurations are readily formed: [Ni(cyclam)(OAc)(2)] x H(2)O adopts the trans-III configuration with axial monode...