The relative importance of aand /?-adrenergic pathways and of their respective intracellular mediators, calcium and CAMP, in the stimulation of phosphorylase a induced by catecholamines was studied in hepatocytes isolated from mature male and female rats. The fractional efflux of 46Ca was used as an index of intracellular calcium activity, Our results show that, in females: 1) the activation of...