Tissue engineering approaches using growth factors and various materials for repairing chronic perforations of the tympanic membrane are being developed, but there are surprisingly few relevant tissue culture models available to test new treatments. Here, we present a simple three-dimensional model system based on micro-dissecting the rat tympanic membrane umbo and grafting it into the membrane...

The effect of the presence of tympanosclerotic plaques in tympanic membrane on the outcome of a myringoplasty procedure was evaluated in this retrospective study. Long-term results of 714 myringoplasties were analyzed, and of these, 555 were eligible for further study. Three groups were studied separately: ears without tympanosclerosis, ears with a plaque not exceeding one third of the tympanic...

INTRODUCTION Tympanoplasty is a standard procedure to repair tympanic membrane perforation. The aim of this study is to evaluate the results of tympanoplasty (hearing improvement and tympanic membrane closure rate) in patients suffering from chronic perforation of the tympanic membrane by considering the prognostic factors. MATERIALS AND METHODS In a prospective study, based on the results of...

This pilot study compared otoprotection provided by trans-tympanic formulations and systemic intraperitoneal administration of L-N-acetylcysteine from cisplatin-induced cochlear oxidative stress. Protection was assessed by measures of hearing loss and cochlear glutathione levels. All groups received an equivalent single dose of L-N-acetylcysteine followed by cisplatin. Cisplatin was administere...

Anatomy.-The tympanic membrane is the same size in the new-born as in the adult. It lies almost horizontal in the plane of the base of the skull, so that its lateral border is almost in the same plane as the superior wall of the meatus. Thus the postero-superior quadrant, the region in which bulging is usually detected, is very near the surface and next the inner limit of the superior wall of t...

BACKGROUND Because the temperature of the body surface depends largely on local blood flow, temperature measurements might provide information on the latter. OBJECTIVE To evaluate the relationship between corneal temperature and finger temperature. METHODS Corneal, finger, and body core temperatures were measured in a relatively unselected population of 266 white persons. Excluded were pers...

PURPOSE To evaluate tympanic bulla healing after experimental ventral osteotomy in cats. METHODS Twenty adult cats were submitted to unilateral ventral bulla osteotomy and divided into two groups: cats of A1 group (n=10) were euthanized at 8 weeks and cats of A2 group (n=10), at 16 weeks postoperative. RESULTS Signs of Horner's syndrome or damage to the inner ear were not found. Open-mouth ...

The stapes is known in several non-mammaliaform cynodonts, although it has only been cursorily studied. Here we thoroughly analyze the stapedial anatomy of several basal cynodonts in a phylogenetic framework. Our study shows that the stapedial anatomy is more variable than previously thought. The morphological variation of the stapes led to the recognition of 11 phylogenetic characters that wer...

OBJECTIVE To determine the long-term effects of ventilation tube insertion on hearing thresholds and tympanic membrane pathologic abnormalities in children with otitis media with effusion. DESIGN Prospective cohort study. SETTING Tertiary care children's hospital, otorhinolaryngology and audiology service. PARTICIPANTS Patients aged 8 to 16 years who participated in a randomized controlle...

Background. Tympanic membrane perforation may occur when ear pressures are excessive, including valsalva maneuver associated with active labor and vaginal delivery. A pressure differential across the eardrum of about 5 psi can cause rupture; the increased intraabdominal pressure spikes repeatedly manifested by "pushing" during second-stage labor easily approach (and may exceed) this level. Mate...