BACKGROUND Twist, a basic helix--loop-helix transcription factor, has been reported to be associated with the development and progression of human cancer. We examined the distribution and expression of Twist in cervical cancer to examine its clinical significance. PATIENTS AND METHODS We examined the distribution and expression of Twist in 101 cervical cancer specimens and determined the asso...

The epithelial-mesenchymal transition (EMT) represents a cellular de-differentiation process that provides cells with the increased plasticity required during embryonic development, tissue remodeling, wound healing and metastasis. Slug and Twist are two key EMT transcription factors (EMT-TFs) that are tightly regulated via ubiquitination and degradation. How Slug and Twist escape degradation an...

Brown fat expresses two PGC-1α isoforms (PGC-1α and NT-PGC-1α) and both play a central role in the regulation of cellular energy metabolism and adaptive thermogenesis by interacting with a wide range of transcription factors including PPARγ, PPARα, ERRα, and NRF1. PGC-1α consists of 797 amino acids, whereas alternative splicing of the PGC-1α gene produces a shorter protein called NT-PGC-1α (aa ...

In a genomewide anoikis suppression screen for metastasis genes, we previously identified the neurotrophic receptor tyrosine kinase TrkB. In mouse xenografts, activated TrkB caused highly invasive and metastatic tumors. Here, we describe that TrkB also induces a strong morphological transformation, resembling epithelial-mesenchymal transition (EMT). This required TrkB kinase activity, a functio...

A set of dynamical equations are derived for a slender tube of isolated magnetic ux generalizing a model due to Spruit. The tube is assumed to consist of eld lines which twist about the tube's axis at some rate q. The equations describe the evolution of the axis and the evolution of the twist. They include the interaction between twist and motions of the axis described as writhing. Through this...

We consider the Melvin Twist of AdS5×S5 under U(1)×U(1) isometry of the boundary S3 of the global AdS5 geometry and identify its field theory dual. We also study the thermodynamics of the Melvin deformed theory. Melvin twist, also known as the T-s-T transformation, is a powerful solution generating technique in supergravity and string theories [1–6]. The procedure relies on having a U(1)× U(1) ...

We give a general treatment of twist-three effects in two-photon reactions. We address the issue of the gauge invariance of the Compton amplitude in generalized Bjorken kinematics and relations of twist-three 'transverse' skewed parton distributions to twist-two ones and interaction dependent three-particle correlation functions. Finally, we discuss leading order evolution of twist-three functi...

Snail1 and Zeb1 are E-cadherin-transcriptional repressors induced during epithelialmesenchymal-transition (EMT). In this article we have analyzed the factors controlling Zeb1 expression during EMT. In NMuMG cells treated with TGF-β, Snail1 RNA and protein are induced one hour after addition of the cytokine preceeding Zeb1 up-regulation that requires six to eight hours. Zeb1 gene expression is c...

service Email alerting top right corner of the article Receive free email alerts when new articles cite this article-sign up in the box at the Background: The antiapoptotic and epithelial–mesenchymal transition activities of Twist have been implicated in the neoplastic transformation and the development of metastasis, respectively. Upregulation of Twist, described in several types of human canc...