نتایج جستجو برای: tumorigenesis antiangiogenesis
تعداد نتایج: 25649 فیلتر نتایج به سال:
The first antivascular endothelial growth factor (anti-VEGF) was developed as an anticancer drug for colonic carcinomas. Since then, anti-VEGFs have developed in scope and indications. They have revolutionized the treatment of exudative macular degeneration and have had a major impact on treatment of several other conditions. This has resulted in an increased number of patients seeking treatmen...
Antiangiogenesis targeting tumor microenvironment synergizes glucuronide prodrug antitumor activity.
PURPOSE This study is aimed at investigating the in vivo antitumor activity of a novel cell-impermeable glucuronide prodrug, 9-aminocamptothecin glucuronide (9ACG), and elucidating the synergistically antitumor effects of antiangiogenesis therapy by targeting the tumor microenvironment. EXPERIMENTAL DESIGN We analyzed the antitumor effects of 9ACG alone or combined with antiangiogenic monoclo...
The process of angiogenesis includes sprouting of new vessels from pre-existing ones, their remodelling and regression. Angiogenesis is a pre-requisite for growth and differentiation of organs and tissues as it allows for supply with nutrients and oxygen (Folkman, 2003). Angiogenesis also plays a key role in many pathological processes, particularly growth and metastasis of tumours (Folkman, 19...
Immune Checkpoint Inhibition in Advanced Bladder and Kidney Cancer: Responses and Further Management
Immune checkpoint inhibitors have an established role in the treatment of newly diagnosed metastatic kidney cancer. Treatment regimens combining nivolumab plus ipilimumab, pembrolizumab axitinib, cabozantinib, and lenvatinib demonstrated superior overall survival compared with sunitinib randomized studies. Response rates vary from 42% to 71.1% these combinations. Atezolizumab been approved for ...
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