INTRODUCTION The aim of this study was to evaluate the levels of p53 protein in serum and urine samples of patients with bladder transitional cell carcinoma (TCC) and their relation with the overexpression of p53 in the tumoral tissue. MATERIALS AND METHODS A total of 39 patients with bladder TCC were evaluated for p53 protein in their serum and urine samples and the overexpression of this ma...

BACKGROUND Tumoral calcinosis is rarely located in spine. A 55-year-old Japanese woman with cervical tumoral calcinosis is presented, along with a review of the literature relating to tumoral calcinosis in the spine. We discussed the etiology, diagnosis, and management of this condition. CASE PRESENTATION We report a case of a patient with cervical tumoral calcinosis with end-stage renal dise...

CORTACTIN is an actin-binding protein critically involved in cellular migration and invasion. Here, we investigated the role of CORTACTIN in the pathophysiology of orohypopharynx carcinoma - one of the major subtypes of head and neck cancer. To this end, we analyzed CORTACTIN expression in tumor tissues from 89 orohypopharynx carcinoma patients in relation to clinical parameters. We found that ...

BACKGROUND Hypothesizing that nutritional status, systemic inflammation and tumoral immune microenvironment play a role as determinants of lung cancer evolution, the purpose of this study was to assess their respective impact on long-term survival in resected non-small cell lung cancers (NSCLC). METHODS AND FINDINGS Clinical, pathological and laboratory data of 303 patients surgically treated...

We investigated the distribution of endometrial lymphatic vessels and expression of forkhead box C2 (FOXC2) in normal endometrium during menstrual cycle and in endometrial adenocarcinoma. Full-thickness uterine samples and endometrial adenocarcinoma samples were collected for immunohistochemical analysis using D2-40 and FOXC2 mouse monoclonal antibodies. The lymphatic vessel density (LVD) of th...

RAC3 is a transcription coactivator, usually overexpressed in several tumors and required to maintain the pluripotency in normal stem cells. In this work we studied the association between RAC3 overexpression on cancer cell stemness and the capacity of this protein to induce cancer stem properties in non tumoral cells. We performed in vitro and in vivo experiments using two strategies: by overe...

Functional involvement of RINF, Retinoid-Inducible Nuclear Factor (CXXC5), in normal and tumoral human myelopoiesis Short title: RINF expression is required for myelopoiesis Frédéric Pendino, Eric Nguyen, Inge Jonassen, Bjarte Dysvik, Abdulkader Azouz, Michel Lanotte, Evelyne Ségal-Bendirdjian, and Johan R. Lillehaug. Department of Molecular Biology, University of Bergen, Norway; INSERM U685, H...

PURPOSE Our purpose was to describe the MR imaging features in a series of spinal intramedullary gangliogliomas and to compare these findings with the MR features of intramedullary astrocytomas and ependymomas. METHODS A retrospective analysis was performed of 76 MR examinations in 27 patients with histologically proved spinal ganglioglioma; these were then compared with imaging findings in a...

Primary involvement of skeletal muscle is a very rare event in ALK-1 positive anaplastic large cell lymphoma (ALCL). We describe a case of a 10-year old boy presenting with a three week history of pain and a palpable firm swelling at the dorsal aspect of the left thigh. Histological examination of the lesion revealed a tumoral and diffuse polymorphic infiltration of the muscle by large lymphoid...

Gastrointestinal malacoplakia is an uncommon condi tion, there being 38 reported cases in the world literature.’ The involvement of the cecum is extremely rare, there being only 6 documented cases.’ Malacoplakia has often been misdiagnosed as a neoplastic lesion in biopsy specimens.2’ 3 It has been more frequently diagnosed as an incidental find ing in autopsy. However it can be easily recogniz...