conclusion in breast cancer after nac, the lesion t2 relaxation time was reduced in the responders, and this finding is potentially useful to assess the response to nac. results in 26 cases with nac, the mean lesion t2 relaxation time before nac was 81.34 ± 13.68 ms, compared with 64.50 ± 8.71 ms after nac. significant differences in the lesion t2 relaxation times existed between the pre- and p...

Radiofrequency magnetic cycles of ex vivo melanoma tumor tissue loaded with Fe3O4 nanoflowers (NF) were measured for several field conditions and compared the a ferrogel (FG) obtained incorporating identical NF in agarose gel. Results studied order to understand reported specific power dissipation (SAR) reduction actual application medium (tumor) comparison typical characterization model as FG....

The contributions of the humoral immune response to melanoma are now widely recognized, with reports positive prognostic value ascribed tumor-infiltrating B cells (TIL-B) and increasing evidence as key predictors patient treatment. There disparate views pro- anti-tumor roles cells. appear play an integral role in forming tumor-associated tertiary lymphoid structures (TLSs) which can further mod...

Extracellular vesicles (EVs), like exosomes and microvesicles, are membrane-bound released by most cell types in response to cellular stress as well normal physiologic conditions. EV plays a vital part communication tumor immunology. Tumor-derived EVs carry wide range of neoantigens have distinct molecular signature that reflects the tumor’s genomic complexities. These tumor-derived provide gla...

background: oct4b1, a novel variant of oct4, is expressed in cancer cell lines and tissues. based on our previous reports, oct4b1 appears to have a crucial role in regulating apoptosis as well as stress response [heat shock proteins (hsps)] pathways. the aim of the present study was to determine the effects of oct4b1 silencing on the expression of high molecular weight hsps in three different h...

Objective(s): Program death 1 (PD-1)/ program death-ligand 1 (PD-L1) pathways, as the main inhibitory checkpoints, induce immunosuppression in the tumor microenvironment (TME). Despite the importance of inhibitor checkpoint receptor (ICR) blockers, their outcomes have been limited by the low immune response rate and induced acquired resistance. Pre-existing tumor-speci...

background: candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. it is speculated that structural and secretory proteins of c. albicans have immunomodulatory effects in cancer. objective: to evaluate the effects of c. albicans structural and secreted proteins on intratumoral cd4/cd8 ratio as well as the survival rate in balb/c t...

introduction: epidermal growth factor receptor (egfr) has been shown to play a critical role in tumor cell growth and its overexpression has been observed in many epithelial tumors. in the field of cancer vaccine research, displaying the peptide mimotope on the surface of phage particles has shown promising results. methods: in this study using m13-pviii phage display system, two constructs wer...