Glioblastoma is a deadly brain cancer with limited treatment options. Targeting chondroitin sulfate proteoglycan 4 (CSPG4, best known as NG2) with the monoclonal antibody mAb9.2.27 and activated natural killer (NK) cells abrogated the tumor growth and prolonged the survival of glioblastoma-bearing animals by favoring the establishment of a pro-inflammatory microenvironment. The combination of N...

In several murine tumor models the adoptive transfer of sensitized lymphoid cells is capable of mediating the regression of established tumor (1-3). Identification of the most appropriate cells for use in adoptive transfer is a major problem. While cells specifically sensitized in vivo or in vitro to unique cancer antigens can be highly effective, it is often difficult to obtain these cells bec...

Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression. Ketogenic diets can deplete tumor-bearing animals from MDSCs and regulatory T cells, thereby i...

e16076 Background: Immunotherapy is effective in treating advanced esophageal squamous cell carcinoma (ESCC), but little known about its role the setting of neoadjuvant therapy. Methods: Data from a retrospective cohort and prospective locally ESCC patients were analyzed. All included had received camrelizumab plus nab-paclitaxel S1 capsule followed by radical esophagectomy. The main purpose th...

Malignant transformation of cells is frequently associated with HLA class I antigen downregulation or loss. This abnormality provides malignant cells with a mechanism to escape control by HLA class I antigen-restricted, tumor antigen-specific cytotoxic T lymphocytes. Surprisingly, HLA class I antigen downregulation or loss by tumor cells is not associated with control of tumor growth by natural...

Tumor immunotherapy has exploited the ability of heat shock proteins to chaperone precursors of antigenic peptides to antigen-presenting cells and to activate efficiently an immune response against tumor-associated antigens. The most common strategy is based on the purification of heat shock protein-peptide complexes from tumor cell lines or from tumor surgical samples for in vivo administratio...

Tumor immunotherapy has exploited the ability of heat shock proteins to chaperone precursors of antigenic peptides to antigen-presenting cells and to activate efficiently an immune response against tumor-associated antigens. The most common strategy is based on the purification of heat shock protein-peptide complexes from tumor cell lines or from tumor surgical samples for in vivo administratio...

MBT-2 in C3H/HeN mice was used as a model to examine cytotoxic activity. The cytotoxic activities examined were those of natural killer cells (NK), lymphokine activated killer cells (LAK), and tumorcidal macrophage (M psi). NK activity increased in early tumor bearers, but LAK and M psi activities increased in middle tumor bearers. NK activity was inhibited in late tumor bearers, but LAK and M ...