A new simple method of evaluating specific cytotoxicity to tuberculoprotein in the study of tuberculin hypersensitivity in vitro by comparing cell populations is presented. Utilizing this technic it was possible to reproduce Rich's results (1, 2) using human tissues of reticuloendothelial origin. The demonstration of the specific cytotoxic phenomenon in tuberculin-sensitive human tissues indica...

adoption of suitable preventive measures have considerably brought down the incidence of the disease within recent years in several countries in Europe. The importance of the study is now being felt by the leading members of our profession who think about the future of our race, for this fell disease invalidates or carries away individuals when they are most likely to be useful to society (i.e....

The expression of the CD69 antigen on CD4 T lymphocytes after in vitro stimulation with purified protein derivative (2 tuberculin units) was used to evaluate the tuberculin reactivities of 52 individuals from four experimental groups: Mycobacterium bovis BCG-vaccinated healthy individuals with a negative tuberculin skin test (TST) result (group A), BCG-vaccinated healthy individuals with a posi...

Fever is a hallmark of tuberculin hypersensitivity. Ever since the dassic papers of von Pirquet (1) and the clinico-pathologic observations of Rich (2), fever has been recognized as a cardinal sign of tuberculous infection. The actual events, however, that lead to elevated body temperature in this disease have remained obscure. Many manifestations of tuberculin hypersensitivity, like the skin t...

OBJECTIVE To estimate the risk of tuberculosis infection among community health agents involved in disease control. METHODS A prospective cohort was followed up from April 2007 to May 2008 in the municipality of Cachoeiro de Itapemirim, Southeastern Brazil. The cohort was composed of 61 community agents, divided between unexposed individuals (n = 37) and exposed individuals (who were followin...

The value of tuberculin skin testing in the diagnosis of active tuberculosis remains uncertain. Interpretation of tuberculin tests would be easier if the tuberculin test profiles in different communities were accurately known. We reviewed 468 Mantoux test reactions in patients coming to Hospital Universiti Sains Malaysia with suspected tuberculosis. Eighty six percent of patients with active tu...

Giant reactions to the tuberculin skin test are extremely rare and have been previously reported almost exclusively in patients with lepromatous leprosy. We herein report a giant tuberculin reaction associated with the homeopathic drug Tuberculinum in a patient with no evidence of active tuberculosis or leprosy.

To the Editor: Several reports, including one by Shands et al (Infect Control Hosp Epidemiol 1994;15:758-760), indicate an apparent widespread high falsepositive rate associated with the use of Aplisol (Parke-Davis) tuberculin material.lj Numerous other reports indicate that this problem is not recent.2-5 To date, investigators have emphasized the cost and increased frequency of false-positive ...