Background Myocardial PVM may be used to assess peak velocities and the times to those peaks (TTP) in order to characterise healthy and pathological regional heart motion [1]. However data on the reproducibility of the technique is limited. A previous breathhold (low resolution) study investigated reproducibility for peak radial and circumferential velocities [2]; however that of TTP measuremen...

Thrombotic thrombocytopenic purpura (TTP) is a rare hematologic syndrome. It is a multisystem disorder characterized by microangiopathic hemolytic anemia and thrombocytopenia and may be accompanied by fever and renal or neurologic abnormalities (1,2). Most adult patients acquire (3) the disease as a result of autoantibodies against ADAMTS13 (i.e., idiopathic TTP), or it is observed in associati...

The TTP/C protocol is a communication protocol for safety-critical real-time applications. It is designed to meet both the cost constraints of the automotive industry and the stringent safety constraints of the aeronautics industry. This is achieved by using the static nature of the TTP/C communication pattern to build relatively cheap communication controllers being supervised by guardians tha...

It has now been 3 years since the von Willebrand factor (VWF)-cleaving protease implicated in thrombocytopenic purpura (TTP) pathogenesis was identified as ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13). More than 50 ADAMTS13 mutations resulting in familial TTP have been reported. Considerable progress has also been realized toward understanding the role o...

We have previously reported the purification of a 37-kd platelet-agglutinating protein (PAP p37) from the plasma of a patient with thrombotic thrombocytopenic purpura (TTP) that was shown to be present in a subset of TTP patients. The platelet agglutination induced by PAP p37 has been shown to be inhibited by lgG from normal human adults and the same TTP patient after recovery. To elucidate the...

Primary polycythemia (PCV) may coexist in otherwise asymptomatic patients particularly in the presence of unsuspecting conditions such as Thrombotic thrombocytopenic purpura (TTP). In presumed "idiopathic TTP," autoimmune conditions such as rheumatoid arthritis (RA) should be investigated as a possible etiology for TTP. Standardization of targeted therapy with immunomodulatory agents may be rec...

Thrombotic thrombocytopenic purpura (TTP) is a rare variant of thrombotic microangiopathy. We report case TTP in Nigerian chronic kidney disease (CKD) patient who was previously on clopidogrel. The features resolved soon after clopidogrel withdrawn. Clopidogrel cardio-protective anti-platelet drug used CKD patients at risk dyspepsia. However, its potential to cause should be recognized and cons...

Background: The microangiopathic hemolytic anemias, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), and disseminated intravascular coagulation (DIC) are life-threatening conditions with significant clinical overlap. Although TTP is classically described by a pentad of signs, the more likely clinical scenario involves a patient with unexplained thrombocytopenia and he...

OBJECTIVE Tristetraprolin (TTP), also known as zinc finger protein 36, is an RNA binding protein that has a significant role in regulating the expression of mRNAs containing AU-rich elements. We postulated that TTP might regulate interleukin (IL)-6 and IL-18 expression in diabetes. This study aimed to test the hypothesis that the levels of TTP are correlated with nephropathy in patients with ty...