نتایج جستجو برای: tspo

تعداد نتایج: 1222  

2016
Eleonora Da Pozzo Chiara Giacomelli Barbara Costa Chiara Cavallini Sabrina Taliani Elisabetta Barresi Federico Da Settimo Claudia Martini

The steroidogenic 18 kDa translocator protein (TSPO) is an emerging, attractive therapeutic tool for several pathological conditions of the nervous system. Here, 13 high affinity TSPO ligands belonging to our previously described N,N-dialkyl-2-phenylindol-3-ylglyoxylamide (PIGA) class were evaluated for their potential ability to affect the cellular Oxidative Metabolism Activity/Proliferation i...

2012
Philippe Corcia Clovis Tauber Johnnie Vercoullie Nicolas Arlicot Caroline Prunier Julien Praline Guillaume Nicolas Yann Venel Caroline Hommet Jean-Louis Baulieu Jean-Philippe Cottier Catherine Roussel Mickael Kassiou Denis Guilloteau Maria-Joao Ribeiro

There is growing evidence of activated microglia and inflammatory processes in the cerebral cortex in amyotrophic lateral sclerosis (ALS). Activated microglia is characterized by increased expression of the 18 kDa translocator protein (TSPO) in the brain and may be a useful biomarker of inflammation. In this study, we evaluated neuroinflammation in ALS patients using a radioligand of TSPO, (18)...

2016
Simona Daniele Elisabetta Barresi Elisa Zappelli Luciana Marinelli Ettore Novellino Federico Da Settimo Sabrina Taliani Maria L. Trincavelli Claudia Martini

The development of multi-target drugs and irreversible modulators of deregulated signalling proteins is the major challenge for improving glioblastoma multiforme (GBM) treatment. Reversible single-target drugs are not sufficient to sustain a therapeutic effect over time and may favour the activation of alternative signalling pathways and the onset of resistance phenomena. Thus, a multi-target c...

2015
Yun Mi Choi Kyung Hoon Kim

Etifoxine (etafenoxine, Stresam®) is a non-benzodiazepine anxiolytic with an anticonvulsant effect. It was developed in the 1960s for anxiety disorders and is currently being studied for its ability to promote peripheral nerve healing and to treat chemotherapy-induced pain. In addition to being mediated by GABAAα2 receptors like benzodiazepines, etifoxine appears to produce anxiolytic effects d...

Journal: :Dementia and geriatric cognitive disorders 2014
C Hommet K Mondon V Camus M J Ribeiro E Beaufils N Arlicot P Corcia M Paccalin F Minier T Gosselin G Page D Guilloteau S Chalon

BACKGROUND/AIMS Neuroinflammation plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Its relationship with underlying β amyloid deposition remains unclear. In vivo visualization of microglial activation has become possible with the development of molecular imaging ligands when used with positron emission tomography (PET). The translocator protein (TSPO) is upregulated during ...

Journal: :hepatitis monthly 0
minghui liu department of tcm, china-japan :union: hospital of jilin university, changchun, china yuchang dou department of tcm, china-japan :union: hospital of jilin university, changchun, china; department of tcm, china-japan :union: hospital of jilin university, changchun, china. tel: +86-43184995840, fax: +86-43184995840 ran sun science research center, china-japan :union: hospital of jilin university, changchun, china yonggui zhang department of gastroenterology, china-japan :union: hospital of jilin university, changchun, china yansong liu department of tcm, china-japan :union: hospital of jilin university, changchun, china

background alcoholic hepatitis (ah) is an acute manifestation of alcoholic liver disease with high mortality rates. objectives our aim was to study the molecular mechanisms of ah. materials and methods the differentially expressed genes (degs) in liver between ah and control cases were identified by analyzing the gse28619 microarray data using t-test. the kyoto encyclopedia of genes and genomes...

2017
Ansel T. Hillmer Daniel Holden Krista Fowles Nabeel Nabulsi Brian L. West Richard E. Carson Kelly P. Cosgrove

BACKGROUND The 18-kDa translocator protein (TSPO) is an important target for assessing neuroimmune function in brain with positron-emission tomography (PET) imaging. The goal of this work was to assess two [11C]PBR28 imaging paradigms for measuring dynamic microglia changes in Macaca mulatta. METHODS Dynamic [11C]PBR28 PET imaging data with arterial blood sampling were acquired to quantify TS...

2013
Efrat Kravitz Inna Gaisler-Salomon Anat Biegon

Early Alzheimer's disease (AD) is characterized by memory loss and hippocampal atrophy with relative sparing of basal ganglia. Activation of glutamate NMDA receptors in the hippocampus is an important step in memory formation. We measured the density of NMDA receptors in samples of hippocampus, entorhinal cortex and basal ganglia obtained from subjects who died with pathologically confirmed AD ...

Journal: :NeuroImage 2012
Jonas Hannestad Jean-Dominique Gallezot Thomas Schafbauer Keunpoong Lim Tracy Kloczynski Evan D. Morris Richard E. Carson Yu-Shin Ding Kelly P. Cosgrove

UNLABELLED Microglia play an essential role in many brain diseases. Microglia are activated by local tissue damage or inflammation, but systemic inflammation can also activate microglia. An important clinical question is whether the effects of systemic inflammation on microglia mediate the deleterious effects of systemic inflammation in diseases such as Alzheimer's dementia, multiple sclerosis,...

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