Aim. This study investigated the effect and mechanism of the Chinese herbal medicine Tangshen Formula (TSF) on GI structure remodeling in the rat model of diabetes. Methods. Type 2 diabetic rats were used. Wet weight per unit length, layer thicknesses, levels of collagens I and III, nuclear factor kappa B (NF-κB), interferon-γ (IFN-γ), interleukin-6 (IL-6), transforming growth factor-β1 (TGF-β1...

An unexpected aspect of the expression of cloned genes is the frequent failure of newly synthesized polypeptide chains to reach their native state, accumulating instead as insoluble inclusion bodies. Amyloid deposits represent a related state associated with a variety of human diseases. The critical folding intermediates at the juncture of productive folding and the off-pathway aggregation reac...

OBJECTIVE To investigate the outcomes of tibial nonunions and bone defects treated with the Taylor Spatial Frame (TSF) using the Ilizarov method. DESIGN Retrospective. SETTING Limb Lengthening and Deformity Service at an academic medical center. PATIENTS Thirty-eight consecutive patients with 38 tibial nonunions were treated with the TSF. There were 23 patients with bone defects (average ...

Time Series Forecasting (TSF) is an important tool to support decision making (e.g., planning production resources). Artificial Neural Networks (ANN) are innate candidates for TSF due to advantages such as nonlinear learning and noise tolerance. However, the search for the best model is a complex task that highly affects the forecasting performance. In this work, we propose two novel Evolutiona...

Plant architecture shows a large degree of developmental plasticity. Some of the key determinants are the timing of the floral transition induced by a systemic flowering signal (florigen) and the branching pattern regulated by key factors such as BRANCHED1 (BRC1). Here, we report that BRC1 interacts with the florigen proteins FLOWERING LOCUS T (FT) and TWIN SISTER OF FT (TSF) but not with TERMI...

School environments may contribute to adolescent behavior, reproductive physiology and body composition (BC). The Nutritional and Health Survey in Taiwan (2010) for 1458 junior high school students was geo-mapped for 30 school environs. Facilities for physical activity (fitness centers, gymnasia and sports stadiums, activity centers and parks), sedentary activities (reading material rental shop...

Sensitivity analysis can provide useful information when one is interested in identifying the parameter θ of a system since it measures the variations of the output u when θ changes. In the literature two different sensitivity functions are frequently used: the traditional sensitivity functions (TSF) and the generalized sensitivity functions (GSF). They can help to determine the time instants w...

Single amino acid substitutions in a protein can cause misfolding and aggregation to occur. Protein misfolding can be rescued by second-site amino acid substitutions called suppressor substitutions (su), commonly through stabilizing the native state of the protein or by increasing the rate of folding. Here we report evidence that su substitutions that rescue bacteriophage P22 temperature-sensit...

On 25 August 1988, a fire broke out in the Chiado area of Lisbon. It is considered one biggest fires an urban Portugal, having destroyed vast built historical heritage and caused several victims. The Portuguese news radio, TSF, was first media outlet to report by starting long special live emission putting into practice innovative model radio journalism for that time Portugal which based on pri...

This article develops a robust feature fusion approach to enhance the classification performance of very high resolution (VHR) remote sensing images. Specifically, novel two-stage multiple (TsF) is proposed, which includes an intragroup and intergroup stages. In first stage, features are grouped by clustering, where redundant information between different types eliminated within each group. The...