نتایج جستجو برای: tryptophanase
تعداد نتایج: 360 فیلتر نتایج به سال:
Glucagon alone, given to adrenalectomized rats, caused induction of tyrosine aminotransferase only in repeated doses. A single dose given with or 5 hours after hydrocortisone enhanced 3-fold the induction of tyrosine aminotransferase by the hydrocortisone. Glucagon did not alter the levels of tryptophan oxygenase in these situations. The simultaneous administration of actinomycin D completely i...
Allosteric interactions in the cupro-heme enzyme tryptophan oxygenase (EC 1.13.11.11) of Pseudomonas acidovorans are shown to be pH-dependent. Increasing the assay pH from 6.0 to 8.0 progressively desensitizes the enzyme from both homotropic and heterotropic ligand interactions. This pH-dependent reversible transition has a pK of 6.2. Hill coefficients for the substrate L-tryptophan of 2.0 and ...
1. The importance of the early depletion of liver haem in the production of porphyria is discussed and further supporting evidence is presented from experiments with tryptophan pyrrolase, under conditions of exacerbation of experimental porphyria by therapeutic and other agents. 2. In addition to the early depletion of pyrrolase haem by porphyrogens, a further depletion is produced when rats ar...
Previous work has shown that lacZ fusions to the cysK, astD, tnaB, and gabT genes in Escherichia coli are activated by self-produced extracellular signals. Using a combination of ethyl acetate extraction, reversed-phase C(18) chromatography, and thin-layer chromatography, we have purified an extracellular activating signal from E. coli supernatants. Mass spectrometry revealed a molecule with an...
MONROE, CARL BLISS. Induction of tryptophan oxygenase and tyrosine aminotransferase in mice. Am. J. Physiol. 214 (6): 141014 14. 1968.-The tryptophan oxygenase and tyrosine aminotransferase of mouse liver can be assayed under the same conditions found to be optimal for the rat liver enzymes. The tryptophan oxygenase existed largely as the inactive apoenzyme form in untreated or hydrocortisone-t...
There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we exam...
IbeR is a regulator present in meningitic Escherichia coli strain E44 that carries a loss-of-function mutation in the stationary-phase (SP) regulatory gene rpoS. In order to determine whether IbeR is an SP regulator in E44, two-dimensional gel electrophoresis and LC-MS were used to compare the proteomes of a noninvasive ibeR deletion mutant BR2 and its parent strain E44 in the SP. Four up-regul...
IAA induces tryptophan oxygenase (EC 1.13.1.12) in Cicer arietinum seedlings and CAMP mimics this action [I]. In seedlings preincubated with IAA, there is also a 3-3.5fold activation of adenyl cyclase as evident from increased incorporation of [8-14C]adenine into [14C]cAMP [2]. Furthermore, the inhibitory effect on germination of C. arietinum caused by inclusion of 8-azadenine in the imbibition...
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