نتایج جستجو برای: trypanosoma brucei
تعداد نتایج: 13966 فیلتر نتایج به سال:
L-alpha-Glycerophosphate dehydrogenase, a component of an oxidase system in Trypanosoma rhodesiense.
Gambiense trypanosomiasis is considered an anthroponotic disease. Consequently, control programs are generally aimed at stopping transmission of Trypanosoma brucei gambiense (T. b. gambiense) by detecting and treating human cases. However, the persistence of numerous foci despite efforts to eliminate this disease questions this strategy as unique tool to pursue the eradication. The role of anim...
Human trypanosomiasis is endemic in Africa and South America. Human African Trypanosomiasis (HAT) also known as sleeping sickness is caused by Trypanosoma brucei rhodesiense (in East and South Africa) or Trypanosoma brucei gambiense (in West and Central Africa)1. Disease due to T.b. rhodesiense progresses rapidly over weeks while disease due to T.b. gambiense tends to be chronic. In both the ca...
TbKif13-2, a member of the microtubule-depolymerising Kinesin-13 family was localised at the tip of the flagellum in Trypanosoma brucei. Its predicted activity suggested a role in the regulation of axonemal length. However, using gene deletion and overexpression of TbKif13-2 we show that, in procyclic T. brucei, this kinesin has only a very limited effect on flagellar length. Gene deletion resu...
Guide RNAs bind antiparallel to their target pre-mRNAs to form editing substrates in reaction cycles that insert or delete uridylates (Us) in most mitochondrial transcripts of trypanosomes. The 5' end of each guide RNA has an anchor sequence that binds to the pre-mRNA by base-pair complementarity. The template sequence in the middle of the guide RNA directs the editing reactions. The 3' ends of...
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