We determined prognostic impact of KRAS, BRAF, PIK3CA and TP53 mutation status and mutation heterogeneity among 164 colorectal cancer (CRC) patients undergoing liver resections for metastatic disease. Mutation status was determined by Sanger sequencing of a total of 422 metastatic deposits. In univariate analysis, KRAS (33.5%), BRAF (6.1%) and PIK3CA (13.4%) mutations each predicted reduced med...

The murine coronavirus [murine hepatitis virus (MHV)] is limited to infection of susceptible mice and murine cell lines by the specificity of the spike glycoprotein (S) for its receptor, murine carcinoembryonic antigen cell adhesion molecule 1a (mCEACAM1a). We have recently shown that 21 aa substitutions and a 7-aa insert in the N-terminal region of S are associated with the extended host range...

Das wissenschaftliche Konsortium Sonderforschungsbereich/ Transregio62 (SFB/TRR-62) verfolgt das Ziel, dass zukünftige technische Systeme CompanionSysteme sein werden. Companion-Systeme sind personalisierte Assistenzsysteme, die ihren Nutzer bei der Bewältigung täglicher Aufgaben unterstützen. Diese Assistenzsysteme zeichnen sich durch Eigenschaften wie Anpassungsfähigkeit, Individualität, Verf...

We investigate the effect of microbubbles on Taylor-Couette flow by means of direct numerical simulations. We employ an Eulerian-Lagrangian approach with a gas-fluid coupling based on the point-force approximation. Added mass, drag, lift, and gravity are taken into account in the modeling of the motion of the individual bubble. We find that very dilute suspensions of small non-deformable bubble...

Abstract On the NASA 2020 rover mission to Jezero crater, remote determination of texture, mineralogy and chemistry rocks is essential quickly thoroughly characterize an area optimize selection samples for return Earth. As part Perseverance payload, SuperCam a suite five techniques that provide critical complementary observations via Laser-Induced Breakdown Spectroscopy (LIBS), Time-Resolved Ra...

The metabolism of H/C-labeled 4(-deoxy-4(-epimethylaminoavermectin B1a (MAB1a) benzoate, the major homologue (>90%) of the avermectin insecticide emamectin benzoate, was studied in laying chickens. Ten Leghorn hens (Gallus domesticus) were orally dosed once daily for 7 days (1 mg/kg of body weight/day). Eggs and excreta were collected daily, and eggs were subsequently separated into whites and ...

To evaluate the safety and efficacy of combining Endostar antiangiogenic therapy with neoadjuvant chemotherapy for the treatment of stage IIIA (N2) NSCLC, we conducted a randomized, controlled, open-label clinical study of 30 NSCLC patients. Patients were randomly assigned to the test or control groups, which received either two cycles of an NP neoadjuvant chemotherapy regimen combined with End...

Previous work showed that C. elegans gon-14 is required for gonadogenesis. Here we report that gon-14 encodes a protein with similarity to LIN-15B, a class B synMuv protein. An extensive region of GON-14 contains blocks of sequence similarity to transposases of the hAT superfamily, but key residues are not conserved, suggesting a distant relationship. GON-14 also contains a putative THAP DNA-bi...