BACKGROUND Besides functioning as chemosensors for a broad range of endogenous and synthetic ligands, transient receptor potential vanilloid (TRPV) 1-4 channels have also been related to capsaicin (TRPV1), pain, and thermal stimuli perception, and itching sensation (TRPV1-4). While the expression of the TRPV1-4 genes has been adequately proved in skin, sensory fibres and keratinocytes, less is ...

Abstract Memory B cells (MBCs) are long-lived and produce high-affinity, generally, class-switched antibodies. Here we use a multiparameter approach involving CD27 to segregate naïve (NBCs), IgD+ unswitched (unsw) MBCs IgG+ or IgA+ (sw) from humans of different age, sex race. Conserved antibody variable gene expression indicates that emerge through unbiased selection NBCs. Integrative analyses ...

Transient receptor potential melastatin-8 (TRPM8), a cationic ion channel is involved in detection of normal cooling-sensation in mammals. TRPM8 activation by cooling or chemical agonists have been shown to produce profound, mechanistically novel analgesia in chronic pain states such as neuropathic pain in rodents. Known TRPM8 agonists such as menthol and icilin have a relatively low potency an...

PURPOSE Transient receptor potential melastatin-8 (TRPM8) is an ion channel expressed extensively in sensory nerves, human prostate and overexpressed in a variety of cancers including prostate, breast, lung, colon and skin melanomas. It is activated by innoxious cooling and chemical stimuli. TRPM8 activation by cooling or chemical agonists is reported to induce profound analgesia in neuropathic...

THE RECENT MODEL ANALYSIS of hypothalamic neuronal thermosensitivity by Wechselberger et al. (this issue) highlights the progress made in identifying ion channels and in elucidating temperature dependencies of their properties as a new perspective for unraveling the neuronal network of temperature regulation (28). Proceeding from sequence homologies, (super-) families of genes encoding a multit...

Kamari is performing a clinical trial (KM001-AB1) evaluating the safety and efficacy of KM001, novel topical TRPV3 inhibitor, in patients with moderate to severe pruritus caused by LSC. cation channel highly expressed keratinocytes affecting proliferation, differentiation inflammation processes can be activated various distinctive triggers. It was implicated pathogenesis chronic related disease...