نتایج جستجو برای: trough
تعداد نتایج: 8646 فیلتر نتایج به سال:
BACKGROUND In the past, impurities in vancomycin formulations were thought to contribute to nephrotoxicity. In contrast, when current, purer formulations are dosed at conventional trough levels (i.e., 5-15 mg/L), the incidence of nephrotoxicity is relatively low. Recent guidelines have recommended targeting higher vancomycin trough levels in treatment of complicated methicillin-resistant Staphy...
BACKGROUND Dolutegravir (DTG) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1), and partly by cytochrome P450 3A (CYP3A). Therefore, we focused on UGT1A1 gene polymorphisms (*6 and *28) in Japanese individuals infected with human immunodeficiency virus (HIV)-1 to examine the relationship between their plasma trough concentration of DTG and gene polymorphis...
BACKGROUND Imatinib mesylate is used in combination with hydroxyurea (HU) in ongoing clinical phase II studies in recurrent glioblastoma multiforme (GBM). CYP3A4 enzyme-inducing antiepileptic drugs (EIAEDs) like carbamazepine, phenytoin, and oxcarbazepine--as well as non-EIAEDs like valproic acid, levetiracetam, and lamotrigine--are frequently used in patients with GBM. Since CYP3A4 is the majo...
To the Editor—We appreciate the opportunity to respond to Dr. Tarchini regarding the important questions he poses in his letter. The following addresses each of his points in turn. First, as has been repeatedly demonstrated, achievement of vancomycin trough concentrations in the range of 15–20 mcg/ mL does not necessarily result in improved outcomes (compared with lower trough concentrations). ...
The appearance of resonant-particle effects in the linear dynamics of electron waves in a plasma whose electrons are trapped in a potential trough is discussed and conditions for the characteristic times involved are derived. For the special case of a parabolic potential trough it is shown that, within a limited time interval, a strong resonant effect may occur, due to the interaction of a wave...
The Nankai Trough marks the location where the Philippine Sea Plate begins subducting beneath the Eurasian Plate. The Nankai Trough subduction system has played an important role in causing many catastrophic earthquakes, a phenomenon observed at many other subduction zones (Ando, 1975). Recent studies have established that fluids play a major role in the physical and chemical evolution of subdu...
We show that long-range correlations for nuclear masses have a significant effect on the synthesis of heavy elements by the r process. As calculated by Delaroche et al. [Phys. Rev. C 81, 014303 (2010)], these correlations suppress magic number effects associated with minor shells. This impacts the calculated abundances before the third r-process peak (at mass number A≈195), where the abundances...
In this study, a new proposed multi-generation system as a promising integrated energy conversion system is studied, and its performance is investigated thermodynamically. The system equipped with parabolic trough collectors and biomass combustor to generate electricity, heating and cooling loads, hydrogen and potable water. A double effect absorption chiller to provide cooling demand, a proton...
Today, dust and dust storms are among the most important environmental problems in the world and Iran, in particular. This study is conducted to identify synoptic patterns of the dust storms in Ardabil Province (Iran) and monitor the origin and pathway of its places. The study period is 34 years for1979 to 2013. The data used in this work are from synoptic stations of Ardabil province and the N...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید