نتایج جستجو برای: troponin

تعداد نتایج: 13375  

Journal: :The New England journal of medicine 2015
Brendan M Everett Maria Mori Brooks Helen E A Vlachos Bernard R Chaitman Robert L Frye Deepak L Bhatt

BACKGROUND Cardiac troponin concentrations are used to identify patients who would benefit from urgent revascularization for acute coronary syndromes. We hypothesized that they might be used in patients with stable ischemic heart disease to identify those at high risk for cardiovascular events who might also benefit from prompt coronary revascularization. METHODS We measured the cardiac tropo...

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2017
Sarah A. Goldstein L. Kristin Newby Derek D. Cyr Megan Neely Thomas F. Lüscher Eileen B. Brown Harvey D. White E. Magnus Ohman Matthew T. Roe Christian W. Hamm

BACKGROUND The relationship between troponin level and outcomes among patients with non-ST-segment elevation ACS is established, but the relationship of troponin level with long-term outcomes among medically managed non-ST-segment elevation ACS patients receiving contemporary antiplatelet therapy is inadequately defined. METHODS AND RESULTS In 6763 medically managed non-ST-segment elevation A...

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Journal: :South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2014
Alex Torborg Lisa Ryan Gary Kantor Bruce M Biccard

BACKGROUND A postoperative troponin leak that was previously considered clinically insignificant has been independently associated with 30-day mortality in unselected surgical patients ≥45 years of age following non-cardiac surgery. OBJECTIVES To determine whether routine troponin surveillance following non-cardiac surgery and initiation of aspirin and statin therapy in troponin-positive pati...

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Journal: :Circulation 2013
Judith A R van Waes Hendrik M Nathoe Jurgen C de Graaff Hans Kemperman Gert Jan de Borst Linda M Peelen Wilton A van Klei

BACKGROUND To identify patients at risk for postoperative myocardial injury and death, measuring cardiac troponin routinely after noncardiac surgery has been suggested. Such monitoring was implemented in our hospital. The aim of this study was to determine the predictive value of postoperative myocardial injury, as measured by troponin elevation, on 30-day mortality after noncardiac surgery. ...

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Journal: :Archives of disease in childhood. Fetal and neonatal edition 2001
S J Clark P Newland C W Yoxall N V Subhedar

BACKGROUND Perinatal asphyxia is associated with cardiac dysfunction. This may be secondary to myocardial ischaemia. Cardiac troponin T is the ideal marker for myocardial necrosis. Elevated levels in cord blood may be associated with intrauterine hypoxia and increased perinatal morbidity. AIMS To establish an upper limit of normal for cardiac troponin T concentration in the cord blood of infa...

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2014
Kiran R Bagale Avinash S. Ingle

It is now well known that, as compared to all other cardiac markers the cardiac Troponin-I and CK-MB are found to be more reliable for the diagnosis of myocardial infarction (MI). The aim of our study was to assess the comparative role of CK-MB and Troponin-I in the diagnosis of non-ST elevation MI (NSTEMI) where there is minimal cardiac damage. Design: The study comprised of 50 patients presen...

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Journal: :British journal of anaesthesia 2015
A Conway Morris

A.S. J. has been consultant to many companies dealing with diagnostics. High-sensitive cardiac troponin T measurements in prediction of non-cardiac complications after major abdominal surgery. Association of cardiac troponin, CK-MB, and postoperative myocardial ischemia with long-term survival after major vascular surgery. Use of clinically based troponin underestimates the cardiac injury in no...

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2007
Paul Robinson Peter J. Griffiths Hugh Watkins Charles S. Redwood

Dilated cardiomyopathy and hypertrophic cardiomyopathy (HCM) can be caused by mutations in thin filament regulatory proteins of the contractile apparatus. In vitro functional assays show that, in general, the presence of dilated cardiomyopathy mutations decreases the Ca sensitivity of contractility, whereas HCM mutations increase it. To assess whether this functional phenomenon was a direct res...

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Journal: :Circulation research 2010
Agnieszka Galińska Victoria Hatch Roger Craig Anne M Murphy Jennifer E Van Eyk C-L Albert Wang William Lehman D Brian Foster

RATIONALE Ca(2+) control of troponin-tropomyosin position on actin regulates cardiac muscle contraction. The inhibitory subunit of troponin, cardiac troponin (cTn)I is primarily responsible for maintaining a tropomyosin conformation that prevents crossbridge cycling. Despite extensive characterization of cTnI, the precise role of its C-terminal domain (residues 193 to 210) is unclear. Mutations...

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Journal: :Stroke 2018
Shadi Yaghi Andrew D Chang Brittany A Ricci Mahesh V Jayaraman Ryan A McTaggart Morgan Hemendinger Priya Narwal Katarina Dakay Brian Mac Grory Shawna M Cutting Tina M Burton Christopher Song Emile Mehanna Matthew Siket Tracy E Madsen Michael Reznik Alexander E Merkler Michael P Lerario Hooman Kamel Mitchell S V Elkind Karen L Furie

BACKGROUND AND PURPOSE Elevated cardiac troponin is a marker of cardiac disease and has been recently shown to be associated with embolic stroke risk. We hypothesize that early elevated troponin levels in the acute stroke setting are more prevalent in patients with embolic stroke subtypes (cardioembolic and embolic stroke of unknown source) as opposed to noncardioembolic subtypes (large-vessel ...

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