Vol. 106 No. 7/8 Page 1 of 5 ABSTRACT Moloney murine leukaemia virus (M-MuLV) is a member of the retrovirus family. Its cloned reverse transcriptase (RT), similarly to HIV type 1 reverse transcriptase (HIV-1 RT), exhibits DNA-polymerase and ribonuclease H (RNase H) activities capable of converting the single-stranded retroviral RNA genome into double-stranded DNA. The latter is then integrated ...

Generally, oxy-trifluoromethylation in olefins is achieved using oxidants and transition metal catalysts. However, labile olefins remain unexplored due to their incompatibility with harsh reaction conditions. Here, unprecedented light-induced oxidant and metal-free tandem radical cyclization–trifluoromethylation and dehydrogenative oxygenation of 1,6-enynes have been achieved using a photoredox...

Bay-region diol epoxides are ultimate carcinogenic metabolites of a number of polycyclic aromatic compounds. Dibenz|a,/t|acridine can form two diastereomeric pairs of these diol epoxides which are not positional!) equivalent as a result of the nitrogen atom at position 7. We have assessed the structure-activity relationships resulting from heterocyclic nitrogen substitution by examining the mut...

      Two series (a and b) of N- substituted heteroaromatic compounds related to clotrimazole were synthesized. Imidazole ring of the clotrimazole was replaced by 2-methylimidazole in series a, and by 2-methyl-4-nitroimidazole in series b. O-cholortrityl moiety of clotrimazole was also replaced by trityl, mono or dimethoxy trityl. Chemical structures...

The electrochemical generation of vinyl carbocations from alkenyl boronic esters and boronates is reported. Using easy-to-handle nucleophilic fluoride reagents, these intermediates are trapped to form fully substituted fluorides. Mechanistic studies support the formation dicoordinated through sequential single-electron oxidation events. Notably, this fluorination features fast reaction times Le...

In most applications of dissolution-DNP, the polarization of nuclei with low gyromagnetic ratios such as C is enhanced directly by irradiating the ESR transitions of radicals with narrow ESR lines such as Trityl at low temperatures T = 1.2 K in polarizing fields B0 6 5 T. In a field B0 = 6.7 T at T = 1.2 K, DNP with TEMPO leads to a rapid build-up of proton polarization P(H) = 91% with sDNP(H) ...

The application of methods developed mostly in this laboratory permitted the synthesis of the fully S,Nprotected heptapeptides N-carbobenzoxy-S-trityl-L-cysteinylS-diphenylmethylL cysteinyl-LalanylglycylLvalyl-S-trityl-L-cysteinyl-L-serine methyl ester (VIII, Figure 21, N-t-butyloxycarbonyl-S-trityl-L-cysteiny1-Sdiphenylmethyl-LcysteinylL-alanylglycyl-LvalylStrityl-L-cysteinyl-L-serine methyl e...