The reduction of the triple bond and carbonyl group of an , ketoalkyne, 4-phenyl-3-butyn-2-one (PBYO), by rat liver microsomes and cytosol was investigated. The triple-bond-reduced product trans-4-phenyl-3-buten-2-one (PBO) and the carbonyl-reduced product 4-phenyl-3-butyn-2-ol (PBYOL) were formed when PBYO was incubated with rat liver microsomes in the presence of NADPH. The triple bond of 1-p...

The reactivity of a reduced heterobimetallic Co(-I)/Zr(IV) complex, ((t)BuNC)Co((i)Pr2PNMes)3Zr(THF) (), with a series of azido and diazo reagents is explored to demonstrate the feasibility of facilitating two-electron redox processes at a formally d(0) Zr(iv) center using the appended Co fragment exclusively as an electron-reservoir. Addition of mesityl or adamantyl azide to affords the termin...

Aryl- and hetaryl-substituted acetylenes undergo regio- stereoselective silylzincation by reaction with [(Me3Si)3Si]2Zn in the presence of Et2Zn (10–110 mol%) as additive. The distinctive feature this addition across C?C triple bond is its trans stereoselectivity. radical nature process supported diagnostic experiments DFT calculations, which also corroborate role played steric effects to obtai...

In the title binuclear iron(III) complex, [Fe(2)(C(14)H(10)N(2)O(2))(3)]·4C(4)H(8)O or [Fe(2)(salda)(3)]·4THF [H(2)salda = 2,2'-(azinidimethyl-ene)diphenolate and THF is tetra-hydro-furan], the ligand possesses a rotationally flexible single N-N bond. Three dinucleating O,N:N',O'-donor ligands provide three diazine (=N-N=) bridges between the metal ions, yielding a binuclear triple helicate str...

Structure-activity relation studies have established that the alkyl side chain in tetrahydrocannabinol (THC) plays a crucial role in the activation of the cannabinoid receptor. Unfortunately, the flexible nature of this side chain has hampered efforts to elucidate the precise nature of the interaction of THC with its receptors. Therefore, a series of analogs with structurally restrained side ch...

The intrinsic acidity of CH2[double bond, length as m-dash]CHXH2, HC[triple bond, length as m-dash]CXH2 (X = N, P, As, Sb) derivatives and of their complexes with BeH2 and BH3 has been investigated by means of high-level density functional theory and molecular orbital ab initio calculations, using as a reference the ethyl saturated analogues. The acidity of the free systems steadily increases d...

In this study, a simplified and effective method was tried to immobilize iron oxide onto a naturally occurring porous diatomite. Experimental resultsfor several physicochemical properties and arsenic edges revealed that iron oxide incorporated into diatomite was amorphous hydrous ferric oxide (HFO). Sorption trends of Fe (25%)-diatomite for both arsenite and arsenate were similar to those of HF...

A detailed study has been completed on the asymmetric transfer hydrogenation (ATH) of a series enones using Ru(II) catalysts. Electron-rich rings adjacent to CO group reduce level reduction compared CC. The ATH reaction can readily discriminate between double and triple bonds ketones, reducing bond but leaving intact in major product.

Phospholipase A2 catalyses the hydrolysis of the ester bond of 3-sn-phosphoglycerides. Here, we report the crystal structures of the free and anisic acid-bound triple mutant (K53,56,120M) of bovine pancreatic phospholipase A2. In the bound triple mutant structure, the small organic molecule p-anisic acid is found in the active site, and one of the carboxylate oxygen atoms is coordinated to the ...

The complete amino acid sequence of the triple-helical domain of human collagen VI was deduced from sequences of appropriate cDNA clones and confirmed to about 50% by Edman degradation of tryptic peptides. This domain consists of three different peptide segments containing some 335-336 amino acid residues originating from central portions of the alpha 1 (VI), alpha 2(VI), and alpha 3(VI) chains...