The recent discovery of DNA methylation in the nematode T.spiralis may raise the possibility of using it as a potential model organism for epigenetic studies instead of C. elegans, which is deficient in this important epigenetic modification. In contrast to the free-living nematode C. elegans, T. spiralis is a parasitic worm that possesses a complicated life cycle and undergoes a complex develo...

The potential role of intestinal intraepithelial lymphocytes (i-IELs) in the generation of host protective immunity after helminth infection was investigated using the Trichinella spiralis (Owen, 1835)/mouse model. In this study we found a significant rise of TCRgamma(delta)+ i-IELs (P < 0.001) concurrent with the jejunal goblet cells (GC) hyperplasia in T. spiralis-infected C57BL mice on day 4...

Mitogen-stimulated lymphocytes recently have been shown to release colony-stimulating activity (CSA), a stimulator of granulopoiesis in vitro. Whether CSA release is a result of specific antigen-lymphocyte interactions has been investigated by determining the ability of spleen lymphocytes isolated from Trichinella spiralis and Bacille Calmette Guerin (BCG) infected mice to release CSA. Lymphocy...

Background: Trichinella spiralis causes trichinosis through ingestion of pork contaminated by its infectivelarvae, resulting in intestinal and muscular phases infection the same host. Stem cells (SCs) treatsome diseases due to their capacity for trans-differentiation immunomodulation.Objective: To assess therapeutic impact mesenchymal stem (MSCs) during andmuscular stages T. spiralis-experiment...

Studies in mice infected with the gastrointestinal nematode parasite Nippostrongylus brasiliensis demonstrated that IL-4/IL-13 activation of Stat6 suppresses development of intestinal mastocytosis and does not contribute to IL-4/IL-13 production, but is still essential for parasite expulsion. Because expulsion of another gastrointestinal nematode, Trichinella spiralis, unlike N. brasiliensis ex...

BACKGROUND Trichinella spiralis is a parasite with unique features. It is a multicellular organism but with an intracellular parasitization and development stage. T. spiralis is the helminthic pathogen that causes zoonotic trichinellosis and afflicts more than 10 million people worldwide, whereas the parasite's biology, especially the developmental regulation is largely unknown. In other organi...

This study deals with the effect of Eimeria nieschulzi infection on the host immune response to Trichinella spiralis. Six male Sprague-Dawley rats were inoculated with 10' and six with 10'; sporulated E. nieschulzi oocysts. On days 2, 8, and 16 postinoculation (PI), two rats from each infected group, and their paired uninfected controls, were killed and mucosal scrapings from their small intest...

CRANDALL, RICHARD B., AND CRANDALL, CATHERIXE 4. 1972. Trichinella spiralis: Immunologic response to infection in mice. Experimen~tnl Purasitology 31, 378-398. Serum IgG1, IgG2. IgM, and IgA levels were measured by radial immunodiffusion in C57B1 mice after infection with 200 Trichinella larvae. IgG, concentrations increased 2to 5-fold during t,he second week of infection; IgA and IgGz levels s...