Bladder cancer has been cited to result from the neoplastic lesion with environmental and/or occupational factors identified as causatives. Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Most of the bladder cancer patients die from the invasive, metastatic TCC that has turned out to be resistant to chemotherapy. T24 cells, a cell line established from a human urina...

Transitional cell carcinoma of the urinary bladder is a multifocal disease and the whole bladder mucosa is more or less involved in the neoplastic process. A mapping study of 5 cystectomy specimens was performed, and cell proliferation was evaluated immunohistochemically using anti-proliferating cell nuclear antigen (PCNA) monoclonal antibody. A correlation between the pathological findings and...

PURPOSE To evaluate the efficacy of fluorescent microsatellite analysis (MSA) for the serological diagnosis of transitional cell carcinoma (TCC) of the urinary tract analyzing free tumor DNA in the serum of cancer patients. EXPERIMENTAL DESIGN We applied fluorescent MSA to detect serum-DNA alterations in patients suffering from bladder and upper urinary tract TCC and prospectively collected f...

The ubiquitin–proteasome system (UPS) participates in the degradation of proteins which play an important role regulating cell cycle, apoptosis, and angiogenesis, as well immune system. These processes are carcinogenesis. Transitional carcinoma (TCC) is one predominant types bladder cancer. relationship between cancer progression has become a topic increasing interest among researchers. In this...

BACKGROUND Transitional cell carcinoma (TCC) in dogs is associated with high morbidity and mortality. Calcitriol and its analog seocalcitol, combined with medium-chain triglyceride (MCT), have potential for the treatment of this disease. MATERIALS AND METHODS TCC cells were treated with calcitriol or seocalcitol, alone or combined with MCT. Cell growth, cell cycle kinetics, vitamin D receptor...

BACKGROUND The most common malignancy in the urinary system has been bladder cancer and the most predominant histologic subtype has been transitional cell carcinoma (TCC). There were many molecular risk factors, related with poor prognosis. One of these factors was expression of epidermal growth factor receptor (EGFR). OBJECTIVES The aim of this study was to evaluate the prevalence of the epi...

OBJECTIVE To determine whether exposure to lawn or garden chemicals was associated with an increased risk of transitional cell carcinoma (TCC) of the urinary bladder in Scottish Terriers. DESIGN Case-control study. ANIMALS 83 Scottish Terriers with TCC (cases) and 83 Scottish Terriers with other health-related conditions (controls). PROCEDURE Owners of study dogs completed a written quest...

fibrous dysplasia of the bone (fdb) is a common, genetic, developmental disorder with a benign course. fdb can be seen anywhere throughout the skeleton. it is usually asymptomatic and found incidentally on imaging studies that are performed for other purposes. although whole body 18 f-flourodeoxyglucose pet/ct (fdg pet/ct) is widely used in tumor imaging, infections and benign pathologies like ...

BACKGROUND Pigment epithelium-derived factor (PEDF) is an anti-angiogenic factor. The purpose of this study is to examine the involvement of PEDF in the angiogenesis and biological behavior of bladder transitional cell carcinoma (TCC). METHODS We examined the expression of PEDF in 99 bladder TCCs and ten non-neoplastic tissues, and evaluated microvessel density (MVD). RESULTS The positive i...