To the Editor: The smooth muscle cell (SMC)–targeted Cre recombination mice are critical tools for in vivo analysis of gene function in the vasculature and for establishing animal models for cardiovascular diseases. Therefore, there is a continuing effort to generate SMCtargeted Cre recombinase mice for in vivo loss-of-gene function studies. Currently, several genetically engineered mice expres...

Peer review under responsibility of Saudi Ophthalmological Society, King Saud University Production and hosting by Elsevier Access this article onlin www.saudiophthaljourn www.sciencedirect.com Ischemia-induced pathological growth of new blood vessels and expansion of extracellular matrix (ECM) in association with the outgrowth of fibrovascular epiretinal membranes at the vitreoretinal interfac...

In most healthy blood vessels, average endothelial cell turnover is very low, with cell lifespan estimates of up to many years—hardly indicative of a cell type that might be expected to undergo substantial proliferative and phenotypic changes in response to external stimuli. This contrasts with the relatively rapid and continuous turnover of many epithelial cell linings, with replacement by gen...

•Salvianolic acid A reduced the viability of DLBCL cells in vitro.•Salvianolic inhibited tumor growth vivo.•Salvianolic regulated MAPK pathways cells. Treatment options are limited patients with diffuse large B-cell lymphoma (DLBCL). Salvianolic (SAA) is a water-soluble phenolic extracted from Salvia miltiorrhiza (Danshen) anti-tumor properties. The anti-leukemic activity SAA found our recent r...