Human cancer cells maintain telomeres by telomerase activity (TA) or by alternative lengthening of telomeres (ALT). We proposed to define the prevalence of the two telomere maintenance mechanisms (TMM), to assess their association with histology, and to compare their prognostic relevance in a series of 93 patients with liposarcoma. ALT was detected by assaying ALT-associated promyelocytic leuke...

The skin of an adult human contains about 20 billion memory T cells. Epithelial barrier tissues are infiltrated by a combination of resident and recirculating T cells in mice, but the relative proportions and functional activities of resident versus recirculating T cells have not been evaluated in human skin. We discriminated resident from recirculating T cells in human-engrafted mice and lymph...

The vector Boundary Element Method (vBEM) is used for the calculation of a matrix that links the tangential components of the current density on the cortical and scalp surface. This so-called transfer matrix is compared to the transfer matrix that links the potential distribution on both surfaces. Forward and inverse calculations are performed to evaluate both types of transfer matrices. Keywor...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xiii Chapter 1: Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1 Examples of Highly-threaded Many-core Architectures . . . . . . . . . . . . 4 1.2 Research Questions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 1.3 Methodology for Performance Modeling . . . . . . . ...

Pyrrolizidine benzamide (+/-)-2, the bridgehead-methyl analog of SC-53116, was prepared and evaluated for 5-HT(4) agonism activity in the rat tunica muscularis (TMM) mucosae assay. Compound (+/-)-2 has an EC(50) of 449 nM in the TMM assay, as compared to 23 nM for SC-53116, and 66 nM for the racemate of SC-53116.

Bu çalışmada, özellikle optik bölgede geniş band soğurma gösteren çok tabakalı bir hiperbolik metamalzeme tasarlanmıştır. Tasarlanan yapıda üç farklı metal (Ag, Au ve Al) yarıiletken malzeme (InGaAs) kullanılmıştır. Hesaplamalarda Transfer Matris Metodundan (TMM) yararlanılmıştır. yöntem kullanılarak tasarlanan yapıların yansıma spektrumları gelme açısına bağlı olarak incelenmiştir. Metal-diele...

An accurate impedance modeling of a multi-stacked on-chip power distributed network (PDN) based on through-silicon-vias (TSVs) is vitally important to estimate the electrical performance in three-dimensional integrated circuits (3D ICs). This paper proposes method for calculating matrix PDN, which mainly consists arbitrarily TSVs and grid-type PDNs. First, real stack-up structure PDN separated ...

When sound propagates in a porous medium, it is attenuated via several energy loss mechanisms which are switched on or off as the excitation frequency varies. The classical way of measuring acoustic materials uses Kundt impedance tube. However, due to its short length, measurements made steady state harmonic regimes. Its lower cutoff often limited few hundreds Hertz. Two long waveguides were as...