The binding of the antitumor drug cis-dichlorodiammineplatinum(II) and its inactive trans isomer with the nucleosome core particle has been investigated. Kinetic studies show that platinum binding increases with incubation time, from a few bound platinum atoms per nucleosome core in the first 0.5 hr to 40-50 after 40 hr. There is no crosslinking or dissociation of nucleosome cores upon platinum...

The purpose of this research is to find out the impact knowledge management towards employee work productivity with mediation competence at PT. Rahayu Perdana Trans. method used quantitative research. population in study were employees Trans who has criteria taken least a Bachelor's degree (S1) & already experience outside 2years, amounting 85 people. data collection technique was carried b...

In the title compound, trans-[PtCl(2)(C(7)H(9)N)(2)], the Pt(II) atom is located on an inversion center and is coordinated by two 3,4-dimethyl-pyridine ligands and two chloride ligands, resulting in a typical slightly distorted square-planar geometry. The crystallographic inversion centre forces the value of the C-N-N-C torsion angle to be linear and the 3,4-dimethyl-pyridine ligands to be copl...

An organometallic molecular turnstile composed of a stator based on an α,ω-diphosphine bearing, in a symmetric fashion, the 2,6-pyridyl diamide moiety as a central tridentate chelating unit and a rotor composed of Pt(II) equipped with two pyridyl groups in trans configuration was designed. The switching between its open and closed states using Pd(II) was investigated both in solution and in the...

In the title compound, [PtI(2)(C(5)H(5)NO)(2)]·2(CH(3))(2)SO, the Pt(II) ion lies on an inversion center and is coordinated in a slightly distorted square-planar environment by two trans iodide ligands and two pyridine N atoms. In the crystal, complex mol-ecules and solvent dimethyl sulfoxide mol-ecules are linked by inter-molecular O-H⋯O hydrogen bonds.

2D [(1)H, (15)N] HSQC NMR spectroscopy has been used to monitor the reaction of fully (15)N-labelled [{trans-PtCl(NH3)2}2(μ-trans-Pt(NH3)2{NH2(CH2)6NH2}2)](4+) (BBR3464 ((15)N-1)) with the 14-mer duplex (5'-{d(ATACATG(7)G(8)TACATA)}-3'·5'-{d(TATG(18)TACCATG(25)TAT)}-3' or I) at pH 5.4 and 298 K, to examine the possible formation of 1,4 and 1,5-GG adducts in both 5'-5' and 3'-3' directions. In a...

The interaction and reactivity of n-octane adsorbed on the (1×1) and (5×20) surfaces of Pt(100) have been examined by reflection-absorption infrared (RAIRS), temperature-programmed reaction (TPRS), andAuger electron (AES) spectroscopies andby low-energy electrondiffraction (LEED). A strongC-H‚‚‚M interaction between the adsorbate and the metal was present on both surfaces at 100 K, as evidenced...

The study of the reactivity of the enantiopure ferrocenyl Schiff base (SC)-[FcCH=N–CH(Me)(C6H5)] (1) (Fc = (η5-C5H5)Fe(η5-C5H4)) with cis-[PtCl2(dmso)2] under different experimental conditions is reported. Four different types of chiral Pt(II) have been isolated and characterized. One of them is the enantiomerically pure trans-(SC)[Pt{κ1-N[FcCH=N–CH(Me)(C6H5)]}Cl2(dmso)] (2a) in which the imine...

Crystal structures of the cyanoplatinates A2[Pt(CN)4X2] (A = Rb, Cs; X = Cl, Br, I) have been determined by single-crystal analysis and X-ray powder diffraction. The compounds were synthesized by metathesis from Ba[Pt(CN)4] · 4 H2O and alkali metal sulfates, and by subsequent oxidation with the respective halogens. The crystals were grown by slowly concentrating respective aqueous solutions. Th...