In the treatment of women with abnormal uterine bleeding, once a thorough history, physical examination, and indicated imaging studies are performed and all significant structural causes are excluded, medical management is the first-line approach. Determining the acuity of the bleeding, the patient's medical history, assessing risk factors, and establishing a diagnosis will individualize their ...

Methods In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries. We randomly assigned women to receive either 1 g intravenous tranexamic acid or matching placebo in addition to usual care. If bleeding continued after 30...

Numerous methods of controlling bleeding during total hip arthroplasty have been used. Thromboplastic agents have been used with some success, but the resultant fibrin layer interposed between the bone and cement weakens the interface. Topical freezing saline and hypotensive anesthesia have proved to be the most effective to date. The goal of this randomized, double blind, controlled study is t...

OBJECTIVES The management of patients receiving oral anticoagulant therapy (OAT) undergoing minor oral surgeries is controversial. This study was designed to evaluate the correlation between International Normalized Ratio (INR) values and the sufficiency of two different local hemostatic measures in controlling postextraction bleeding in anticoagulated patients. MATERIALS AND METHODS One hund...

Acute renal failure can be the result of acute renal cortical necrosis (RCN), which commonly occurs from complications occurring during pregnancy. RCN is rarely caused by medications, although tranexamic acid, which is used in patients with acute bleeding for its antifibrinolytic effects, reportedly causes acute RCN in rare cases. An 82-year-old woman experienced gastrointestinal bleeding after...

We present the case of a 51-year-old moderate hemophiliac with gingival bleeding due to papillary inflammation and adherence in the molar area 47. After dental diagnosis a calculus was removed and 30% trichloroacetic acid was placed by a pressurized applicator for five seconds; the procedure was repeated until the bleeding stopped, then tranexamic acid was placed by a gauze. The patient chewed ...

BACKGROUND There are various complications that can occur in septorhinoplasty, most of which are related to postoperative failure to achieve the desired aesthetic result. However, there are also many other complications, including postoperative bleeding, which is one of the most common nonaesthetic-related complications. OBJECTIVE The present study was a prospective analysis involving a total...

Some solutions, as the administration of antifibrinolytic drugs (tranexamic acid), have been proposed to reduce the bleeding on a TKR surgery and to decrease the number of transfusions. Hyperfibrinolysis is considered being the major cause of postoperative bleeding after TKA surgery [10-14], the fibrinolytic system is activated in the first hours after surgery increasing the postoperative bleed...