نتایج جستجو برای: traf3

تعداد نتایج: 406  

Journal: :Genes & development 1999
M A Lomaga W C Yeh I Sarosi G S Duncan C Furlonger A Ho S Morony C Capparelli G Van S Kaufman A van der Heiden A Itie A Wakeham W Khoo T Sasaki Z Cao J M Penninger C J Paige D L Lacey C R Dunstan W J Boyle D V Goeddel T W Mak

Bone resorption and remodeling is an intricately controlled, physiological process that requires the function of osteoclasts. The processes governing both the differentiation and activation of osteoclasts involve signals induced by osteoprotegerin ligand (OPGL), a member of tumor necrosis factor (TNF) superfamily, and its cognate receptor RANK. The molecular mechanisms of the intracellular sign...

2017
Yvonne Y Li Grace T Y Chung Vivian W Y Lui Ka-Fai To Brigette B Y Ma Chit Chow John K S Woo Kevin Y Yip Jeongsun Seo Edwin P Hui Michael K F Mak Maria Rusan Nicole G Chau Yvonne Y Y Or Marcus H N Law Peggy P Y Law Zoey W Y Liu Hoi-Lam Ngan Pok-Man Hau Krista R Verhoeft Peony H Y Poon Seong-Keun Yoo Jong-Yeon Shin Sau-Dan Lee Samantha W M Lun Lin Jia Anthony W H Chan Jason Y K Chan Paul B S Lai Choi-Yi Fung Suet-Ting Hung Lin Wang Ann Margaret V Chang Simion I Chiosea Matthew L Hedberg Sai-Wah Tsao Andrew C van Hasselt Anthony T C Chan Jennifer R Grandis Peter S Hammerman Kwok-Wai Lo

Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC genomic data hinders the understanding of NPC biology, disease progression and rational therapy design. Here we performed whole-exome sequencing (WES) on 111 micro-dissected EBV-positive NPCs, with 15 cases subjected to f...

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