نتایج جستجو برای: tpa

تعداد نتایج: 6413  

Journal: :Journal of cellular physiology 1989
P Csermely J Somogyi

12-0-tetradecanoyl-phorbol-13-acetate (TPA) can significantly reduce the Ca-ionophore-induced rise in the intracellular calcium concentration (Cai) of T lymphocytes measured by quin2 or fura-2 fluorescence. This counteraction of TPA is maximal at a preincubation of 90 min at TPA concentrations higher than 20 nM. 45Ca uptake and efflux measurements directly indicate that TPA does not activate th...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Chan Y Shin Mitchell Kundel David G Wells

Long-term synaptic plasticity is both protein synthesis-dependent and synapse-specific. Therefore, the identity of the newly synthesized proteins, their localization, and mechanism of regulation are critical to our understanding of this process. Tissue plasminogen activator (tPA) is a secreted protease required for some forms of long-term synaptic plasticity. Here, we show tPA activity is rapid...

2013
Christian Foerch Nathanael L. Rosidi Frieder Schlunk Arne Lauer Flor A. Cianchetti Emiri Mandeville Ken Arai Kazim Yigitkanli Xiang Fan Xiaoying Wang Klaus van Leyen Helmuth Steinmetz Chris B. Schaffer Eng H. Lo

Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH). Surprisingly, however, the assumption that tPA will worsen ICH has never been biologically tested. Here, we assessed the effects of tPA in two models of ICH....

Journal: :The Journal of pharmacology and experimental therapeutics 2005
Gina E Avila Xi Zheng Xiao Xing Cui Amanda D Ryan Annette Hansson Junghan Suh Arnold B Rabson Richard L Chang Weichung Joe Shih Yong Lin Pamela Crowell Yao Ping Lu You Rong Lou Allan H Conney

Treatment of cultured PANC-1, MIA PaCa-2, and BxPC-3 human pancreatic adenocarcinoma cells with 0.1 to 1.6 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 96 h inhibited the proliferation of these cells in a dose-dependent manner, and PANC-1 and MIA PaCa-2 cells were more sensitive to TPA than BxPC-3 cells. Inhibition of proliferation by TPA in PANC-1 cells was associated with an increase in ...

Journal: :Stroke 2010
Zhong-Song Shi Yince Loh Gary Walker Gary R Duckwiler

BACKGROUND AND PURPOSE Intracranial mechanical thrombectomy is a therapeutic option for acute ischemic stroke patients failing intravenous tissue plasminogen activator (IV tPA). We compared patients treated by mechanical embolus removal in cerebral ischemia (MERCI) thrombectomy after failed IV tPA with those treated with thrombectomy alone. METHODS We pooled MERCI and Multi MERCI study patien...

Journal: :Circulation 2009
Nancy J Brown Mias Pretorius

BACKGROUND A nitric oxide-independent response, possibly mediated by hyperpolarization, regulates vascular tone, acting as a compensatory mechanism in the presence of impaired nitric oxide availability. Cytochrome P450 2C9 (CYP 2C9) is a source of endothelium-derived hyperpolarizing factors and modulates tissue-type plasminogen activator (tPA) release from endothelial cells; however, no effect ...

2006
Ali A. Yashruti Kaveh Berjesteh Steven M. Taffet

There has been much recent interest in the role of a calcium-dependent, phospholipid-dependcnt protein kinase (PKC) in regulation of macro phage function and growth. In order to better define the role of PKC in these processes we have developed mutants of the RAW264 macrophagelike cell line that are resistant to the growth-inhibiting effects of 12-0tetradecanoylphorbol-13-acetate (TPA), a poten...

Journal: :Stroke 2011
Jeffrey A Switzer David C Hess Adviye Ergul Jennifer L Waller Livia S Machado Vera Portik-Dobos L Creed Pettigrew Wayne M Clark Susan C Fagan

BACKGROUND AND PURPOSE Plasma matrix metalloproteinase-9 levels predict posttissue plasminogen activator (tPA) hemorrhage. METHODS The authors investigated the effect of minocycline on plasma matrix metalloproteinase-9 in acute ischemic stroke in the Minocycline to Improve Neurological Outcome in Stroke (MINOS) trial and a comparison group. RESULTS Matrix metalloproteinase-9 level decreased...

Journal: :Blood 2011
Yuko Suzuki Hideki Yasui Tomasz Brzoska Hideo Mogami Tetsumei Urano

In a previous study, we demonstrated unique secretory dynamics of tissue plasminogen activator (tPA) in which tPA was retained on the cell surface in a heavy chain-dependent manner after exocytosis from secretory granules in vascular endothelial cells. Here, we examined how retained tPA expresses its enzymatic activity. Retained tPA effectively increased the lysine binding site-dependent bindin...

Journal: :Stroke 2000
P A Lapchak D F Chapman J A Zivin

BACKGROUND AND PURPOSE A potentially dangerous side effect associated with tissue plasminogen activator (tPA) use is cerebral hemorrhage. We have focused on developing drugs that could be administered with tPA to reduce the rate of hemorrhage. Since recent studies suggest that various matrix metalloproteinases (MMPs) are important in tumor necrosis factor-alpha production and membrane and vesse...

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