*Agency for Toxic Substances and Disease Registry. 1989. Decision guide for identifying substance-specific data needs related to toxicological profiles; Notice. Fed Regist 54(174):37618-37634.

After decades of dysfunction, the Toxic Substances Control Act has been overhauled with provisions that promise better protection against potentially harmful chemicals.

These comments respond to a Federal Register notice (call for comments) by the Agency for Toxic Substances and Disease Registry (ATSDR) in the Department of Health and Human Services [Federal Register 69(245): 76768-76769 (December 22, 2004)], designated [ATSDR202]. The comments primarily relate to the notice of availability of a “Guidance Manual for the Assessment of Joint Toxic Action of Chem...

The Agency for Toxic Substances and Disease Reg­ istry (ATSDR) derives minimal risk levels (MRLs) to assist in evaluating risk of adverse health effects in individuals exposed to hazardous substances. MRLs are derived from published values identifying no-ob­ served-adverse-effect levels (NOAELs) or lowest-ob­ served-adverse-effect levels (LOAELs) in animal or hu­ man studies. The most sensitive...

Adolescents have access to a variety of legal or illicit substances that they use to alter their mood or "get high." The purpose of this review is to provide an overview of common substances adolescents use to get high, including the illicit substances synthetic marijuana or "Spice," salvia, MDMA, synthetic cathinones, and 2C-E. Dextromethorphan and energy drinks are easily accessible substance...

The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) [42 U.S.C. 9601 et seq.], as amended by the Superfund Amendments and Reauthorization Act (SARA) [Pub. L. 99–499], requires that the Agency for Toxic Substances and Disease Registry (ATSDR) develop jointly with the U.S. Environmental Protection Agency (EPA), in order of priority, a list of hazardous substances mos...

Toxic Epidermal Necrolysis (TEN) is a rare and often fatal muco-cutaneous disease usually related to severe adverse drug reaction. The standard treatment of TEN remains controversial and to our knowledge, all reports in literature are mostly concentrated on systemic therapy. On the contrary, no report deals with deep skin scars that may occur. We therefore present an original case of a severe s...

Background Stevens-Johnson syndrome (SJS) / Toxic epidermal necrolysis (TEN) is a rare, severe, and occasionally fatal skin reaction caused mainly by medications. The reported mortality associated with TEN varies from 10-70%. SCORTEN, a severity-of-illness score which estimates the mortality in TEN has been developed and validated. Malignancy was considered as 1 of the 7 independent prognostic ...

The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) [42 U.S.C. 9601 et seq.], as amended by the Superfund Amendments and Reauthorization Act (SARA) [Pub. L. 99–499], requires that the Agency for Toxic Substances and Disease Registry (ATSDR) develop jointly with the U.S. Environmental Protection Agency (EPA), in order of priority, a list of hazardous substances mos...

A risk assessment study was conducted to predict the expected hazardous influence on the ecosystem resulted from urbanization and industrialization activities at Helwan area, Egypt. To achieve these goals, soils, plants and water samples were collected from Helwan area, and their total concentrations of inorganic contaminants (Cd, Cr, Co, Cu, Fe, Mn, Ni, Pb, and Zn) and organic pollutants; such...