The new complexity arising from the genome sequencing projects requires new comprehensive post-genomic strategies: advanced studies in regulatory mechanisms, application of new high-throughput technologies at a genome-wide scale, at the different levels of cellular complexity (genome, transcriptome, proteome and metabolome), efficient analysis of the results, and application of new bioinformati...

For 35 years, Arnstein's ladder of citizen participation has been a touchstone for policy makers and practitioners promoting user involvement. This article critically assesses Arnstein's writing in relation to user involvement in health drawing on evidence from the United Kingdom, the Netherlands, Finland, Sweden and Canada. Arnstein's model, however, by solely emphasizing power, limits effecti...

A software design process for mapping real-time applications onto massively parallel processors is described. The design methodology incorporates a software test bench used to evaluate the level of real-time performance the processing nodes are capable of delivering. The final integration step maintains the simple test bench interfaces and reduces the complexity of integrating the components to...

The performance of a fully parallel direct solver for large sparse symmetric positive deenite systems of linear equations is demonstrated. The solver is designed for distributed-memory, message-passing parallel computer systems. All phases of the computation, including symbolic processing as well as numeric factorization and triangular solution, are performed in parallel. A parallel Cartesian n...

Comparative effectiveness research incorporates study designs extending beyond the randomized controlled trial (RCT) [1], which is the touchstone for demonstrating therapeutic efficacy. The litany of RCT flaws is often recited: not real world, not real patients, not real settings, not available, not timely, and not affordable. Although not every RCT is well designed, there are established narra...

We are developing a compiler and runtime support system called PASSION: Parallel And Scalable Software for Input-Output, to translate out-of-core data-parallel programs to message passing node programs with explicit parallel I/O. This paper describes the design and implementation of the runtime system used in PASSION. We explain the basic model used by the compiler and runtime system. We descri...

In this paper, we propose a model for parallel computation, tile C3-modcl. The C3 _ model evaluates, for a given parallel algorithm and target architecture, the complexity of computation, the pattern of communication, and the potential congestion arising during communication. A metric for estimating the effect of link and processor congestion on the performance of a communication operation is d...

Introduction: The work of the PRISM lab draws upon advances in data acquisition techniques, computer modeling and visualization, and rapid prototyping technologies. In addition, the lab has made significant strides in developing 3D “digital libraries” and unique immersive interactive display techniques. PRISM research continues to exploit the unique virtual space of the computer to pre-visualiz...

In this paper, a novel design method for bandpass filter with attenuation poles (BAP) is presented. The changed inverter element values due to inserting either capacitors or inductors can be optimized using the linear relationship between inverter element values of a conventional bandpass filter (BPF) and those of the BAP using the Touchstone program. A 1800–1825MHz bandpass filter with attenua...

I present some of the research activities of my group in Vision as a Grand Challenge problem whose solution is estimated to need the power of TTop/s computers. Visual information representations which are motivated by the function of the primary visual cortex are computed. In the case of simple objects such as convex polygons, these representations allow straightforward interpretation for objec...