The extracellular matrix (ECM) may contribute to the drug resistance of a solid tumor by preventing the penetration of therapeutic agents. We measured differences in interstitial resistance to macromolecule (IgG) motion in four tumor types and found an unexpected correspondence between transport resistance and the mechanical stiffness. The interstitial diffusion coefficient of IgG was measured ...

The hydraulic resistances of the intima and media determine water flux and the advection of macromolecules into and across the arterial wall. Despite several experimental and computational studies, these transport processes and their dependence on transmural pressure remain incompletely understood. Here, we use a combination of experimental and computational methods to ascertain how the hydraul...

Applications of neural machine interfaces have received increased attention during the last decades. It is crucial to realize the continuous control of prosthetic devices based on biological signals. In order to deal with the highly nonlinear relationship between the Electromyography (EMG) signals and motion, this study presents a novel decoding approach which employs multi-output support vecto...

Support vector machines are a popular machine learning method for many classification tasks in biology and chemistry. In addition, the support vector regression (SVR) variant is widely used for numerical property predictions. In chemoinformatics and pharmaceutical research, SVR has become the probably most popular approach for modeling of non-linear structure-activity relationships (SARs) and p...

Inverse quantitative structure-activity relationship (QSAR) modeling encompasses the generation of compound structures from values of descriptors corresponding to high activity predicted with a given QSAR model. Structure generation proceeds from descriptor coordinates optimized for activity prediction. Herein, we concentrate on the first phase of the inverse QSAR process and introduce a new me...

introduction: this research was aimed at examining acute responses of hormones such as growth hormone (gh), total testosterone (tt), free testosterone (ft), free fatty acid (ffa) and cortisol to resistance (r), endurance (e) and endurance-resistance (er) exercise. methods: the participants of this study were 10 healthy young men. r protocol included bench press, lateral pull down, leg extension...

hydraulic attributes play important role in hydrological studies, soil conservation, designing irrigation and drainage systems, soil conservation, and controlling soil erosion in watersheds. their measurements are very tedious and time consuming and due to high spatial variability, a large number of measurements are required for obtaining reliable values. nowadays, prediction of these attribute...

Suboptimal levels of phosphorus (P) strongly inhibited leaf expansion in young cotton (Gossypium hirsutum L.) plants during the daytime, but had little effect at night. The effect of P was primarily on cell expansion. Compared to plants grown on high P, plants grown on low P had lower leaf water potentials and transpiration rates, and greater diurnal fluctuations in leaf water potential. Hydrau...

A significant increase in drought events frequency is predicted for the next decades induced by climate change, potentially affecting plant species mortality rates and distributions worldwide. The main trigger of plant mortality is xylem hydraulic failure due to embolism and induced by the low pressures at which water is transported through xylem. As the Mediterranean basin will be severely aff...

abstract in this study, the effect of suspended load transport on the characteristics of submerged hydraulic jump (shj) in a rectangular channel was investigated experimentally. sediment concentration and jet froude numbers in the range of 0.424%-16.15% and 1.93-4.96, respectively, were considered. tow grain size 0.15 and 0.03 mm were used in the experiments. characteristics of submerged hydrau...