Using isogenic mouse embryonic fibroblasts and human cancer cell lines, we show that cells defective in base excision repair (BER) display a cisplatin-specific resistant phenotype. This was accompanied by enhanced repair of cisplatin interstrand cross-links (ICLs) and ICL-induced DNA double strand breaks, but not intrastrand adducts. Cisplatin induces abasic sites with a reduced accumulation in...

The Integrated Completed Likelihood (ICL) criterion has been proposed by Biernacki et al. (2000) in the model-based clustering framework to select a relevant number of classes and has been used by statisticians in various application areas. A theoretical study of this criterion is proposed. A contrast related to the clustering objective is introduced: the conditional classification likelihood. ...

The toric Hilbert scheme is a parameter space for all ideals with the same multi-graded Hilbert function as a given toric ideal. Unlike the classical Hilbert scheme, it is unknown whether toric Hilbert schemes are connected. We construct a graph on all the monomial ideals on the scheme, called the flip graph, and prove that the toric Hilbert scheme is connected if and only if the flip graph is ...

The main purpose of this paper is to give a simple and non-combinatorial proof of the toric Mori theory. Here, the toric Mori theory means the (log) Minimal Model Program (MMP, for short) for toric varieties. We minimize the arguments on fans and their decompositions. We recommend this paper to the following people: (A) those who are uncomfortable with manipulating fans and their decompositions...

UNLABELLED The study shows a promising next-generation surgical option for the correction of moderate to high ametropia. Hole implantable collamer lens (ICL), STAAR Surgical, is a posterior chamber phakic intraocular lens with a central artificial hole. As yet, however, no long-term comparison of the clinical results of the implantation of ICLs with and without such a hole has hitherto been con...

The hypothesis that cellular hypertrophy in congestive heart failure (CHF) modulates mechanosensitive (ie, swelling- or stretch-activated) anion channels was tested. Digital video microscopy and amphotericin-perforated-patch voltage clamp were used to measure cell volume and ion currents in ventricular myocytes isolated from normal dogs and dogs with rapid ventricular pacing-induced CHF. In nor...

The purpose of this review is to summarize relevant data from publications appearing in the peer-reviewed scientific literature over the past decade since US Food and Drug Administration approval of the implantable collamer lens (ICL), and, in particular, to review studies relating to sizing methodology, safety, and effectiveness, as well as more recent studies reporting clinical outcomes of th...

Background: Patients with high myopia have higher risk of eye diseases. Currently, Implantable collamer lens (ICL) implantation is one of the widely used refractive intraocular lens surgical intervention methods. Purpose: To evaluate the effectiveness of implantable collamer lens (ICL) implantation in high myopia patients and the changes in wavefront aberrations after the operation. Methods: Th...

In a galaxy cluster, the relative spatial distributions of dark matter, member galaxies, gas, and intracluster light (ICL) may connote their mutual interactions over cluster evolution. However, it is challenging problem to provide quantitative measure for shape matching between two multi-dimensional scalar distributions. We present novel methodology, named {\em Weighted Overlap Coefficient (WOC...

We treat a generalization of Danilov’s vanishing theorem on toric polyhedra. A toric polyhedron is a reduced closed subscheme of a toric variety that are partial unions of the orbits of the torus action. We also give a proof of the E1-degeneration of Hodge to de Rham type spectral sequence for toric polyhedra in any characteristic.