نتایج جستجو برای: toluene alkylation

تعداد نتایج: 13620  

Journal: :Biopolymers 1990
M S Broido M Mezei

Alkylation of the sugar-phosphate backbone of DNA can result upon exposure to several potent carcinogens, inducing DNA misfunction. In order to assess the structural and energetic changes in DNA helices induced by such alkylation, we have performed AMBER-based analyses on phosphotriester containing analogues of (d-[GGAATTCC])2. Fourteen analogues of the nonalkylated oligomer were examined, each...

Journal: :Molecules 2017
Eszter Kókai Judit Halász András Dancsó József Nagy Gyula Simig Balázs Volk

The chemistry of the 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one (1,3-diazaoxindole) compound family, possessing a drug-like scaffold, is unexplored. In this study, the alkylation reactions of N(7)-unsubstituted 5-isopropyl-1,3-diazaoxindoles bearing various substituents at the C(2) position have been investigated. The starting compounds were synthesized from the C(5)-unsubstituted parent comp...

Journal: :Journal of bacteriology 1998
K Kim S Lee K Lee D Lim

To understand the mechanism underlying toluene resistance of a toluene-tolerant bacterium, Pseudomonas putida GM73, we carried out Tn5 mutagenesis and isolated eight toluene-sensitive mutants. None of the mutants grew in the presence of 20% (vol/vol) toluene in growth medium but exhibited differential sensitivity to toluene. When wild-type cells were treated with toluene (1% [vol/vol]) for 5 mi...

Journal: :Applied and environmental microbiology 1990
D R Lovley D J Lonergan

The dissimilatory Fe(III) reducer, GS-15, is the first microorganism known to couple the oxidation of aromatic compounds to the reduction of Fe(III) and the first example of a pure culture of any kind known to anaerobically oxidize an aromatic hydrocarbon, toluene. In this study, the metabolism of toluene, phenol, and p-cresol by GS-15 was investigated in more detail. GS-15 grew in an anaerobic...

Journal: :Applied and environmental microbiology 2004
Yoshifumi Shinoda Yasuyoshi Sakai Hiroshi Uenishi Yasumitsu Uchihashi Akira Hiraishi Hideaki Yukawa Hiroya Yurimoto Nobuo Kato

A newly isolated denitrifying bacterium, Thauera sp. strain DNT-1, grew on toluene as the sole carbon and energy source under both aerobic and anaerobic conditions. When this strain was cultivated under oxygen-limiting conditions with nitrate, first toluene was degraded as oxygen was consumed, while later toluene was degraded as nitrate was reduced. Biochemical observations indicated that initi...

Journal: :Acta neurobiologiae experimentalis 2011
Alfonso Alfaro-Rodríguez Antonio Bueno-Nava Rigoberto González-Piña Emilio Arch-Tirado Javier Vargas-Sánchez Alberto Avila-Luna

Toluene, found in glues and cleaners, is among the inhalants most commonly abused by workers and young drug addicts. In this study, we examined the changes in sleep patterns and monoamine content induced by chronic toluene exposure. Rats were chronically exposed to toluene vapors beginning at 30 days of age for a duration of 30 days. Experiment I was performed in a control group (n=10) and a ch...

Journal: :Applied and environmental microbiology 1991
M S Shields S O Montgomery S M Cuskey P J Chapman P H Pritchard

Pseudomonas cepacia G4 possesses a novel pathway of toluene catabolism that is shown to be responsible for the degradation of trichloroethylene (TCE). This pathway involves conversion of toluene via o-cresol to 3-methylcatechol. In order to determine the enzyme of toluene degradation that is responsible for TCE degradation, chemically induced mutants, blocked in the toluene ortho-monooxygenase ...

Journal: :Occupational and environmental medicine 1994
E W Hjelm A Löf A Sato A Colmsjö B O Lundmark A Norström

This study was undertaken to evaluate the influence of a carbohydrate restricted diet, a subacute ethanol intake, and their combined effect on the kinetics of toluene in humans. Eight healthy male volunteers were exposed by inhalation at four different occasions to 200 mg/m3 2H8-toluene for two hours at a work load of 50 W after a one week low (30%) carbohydrate (CH) diet or high (60%) CH diet ...

2011
Olivier Jackowski Antoine Bussi Isabelle Baussanne Eric Peyrin

Major increases of the selectivity and/or reactivity in aminosugar and sugar O-alkylation were observed in the presence of tetrabutylammonium fluoride (TBAF) in comparison to TBAI under phase-transfer conditions or in solution. The presence of TBAF allowed the selective and rapid alkylation of the 6hydroxyl function of neamine and efficient preparation of protected intermediates useful in synth...

Journal: :The Journal of organic chemistry 2002
Ralph Nicholas Salvatore Advait S Nagle Kyung Woon Jung

A novel method for the mono-N-alkylation of primary amines, diamines, and polyamines was developed using cesium bases in order to prepare secondary amines efficiently. A cesium base not only promoted alkylation of primary amines but also suppressed overalkylations of the produced secondary amines. Various amines, alkyl bromides, and alkyl sulfonates were examined, and the results demonstrated t...

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