نتایج جستجو برای: toll like receptor

تعداد نتایج: 1178421  

Journal: :Cell reports 2014
Isabelle K Vila Pierre-Marie Badin Marie-Adeline Marques Laurent Monbrun Corinne Lefort Lucile Mir Katie Louche Virginie Bourlier Balbine Roussel Philippe Gui Jacques Grober Vladimír Štich Lenka Rossmeislová Alexia Zakaroff-Girard Anne Bouloumié Nathalie Viguerie Cedric Moro Geneviève Tavernier Dominique Langin

Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and progression of fibrosis along with adipocyte metabolic dysfunction and death. Adipose tissue fibr...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه ارومیه - دانشکده دامپزشکی 1391

سلول های بنیادی مزانشیمال، سلولهای بنیادی بالغی هستندکه به بعنوان سلول های پیش ساز غیر خون ساز وچند توانی معرفی می شوند که در طیف وسیعی از بافتهای بالغ بدن یافت می شوند. toll like receptor(tlr) یکی از گیرنده های ها ایمنی بیان شده در سطح سلول های بنیادی مزانشیمال می باشد که می تواند طیف وسیعی از عملکرد های سلول را تحت الشعاع قراردهند.اخیراً مشخص شده است تحریک ویژه tlrدر سطح سلول های بنیادی مزانش...

Journal: :jundishapur journal of microbiology 0
yijie guo department of pathogenic microbiology and immunology, school of basic medical sciences, xi’an jiao tong university, xi’an, china; graduate school of agricultural science, tohoku university, sendai, japan; department of pathogenic microbiology and immunology, school of basic medical sciences, xi’an jiao tong university, xi’an, china. tel: +86-2985267814, fax: +86-2985267814 cuiping ding department of pathogenic microbiology and immunology, school of basic medical sciences, xi’an jiao tong university, xi’an, china bo zhang graduate school of agricultural science, tohoku university, sendai, japan jun xu faculty of science and engineering, iwate university, iwate, japan meng xun department of pathogenic microbiology and immunology, school of basic medical sciences, xi’an jiao tong university, xi’an, china jiru xu department of pathogenic microbiology and immunology, school of basic medical sciences, xi’an jiao tong university, xi’an, china

conclusions in this study, the l-lps immune response of bovine cells was significant, indicating that tlr2 is the predominant receptor for l-lps. due to l-lps endotoxin-like activity, we found a strategy through using bmap-28 to prevent l-lps-induced tlr2-dependent immune activation in bovine cells. materials and methods in this study, l-lps-induced proinflammatory cytokine production in bovine...

Journal: :Haematologica 2011
Eleni Arvaniti Stavroula Ntoufa Nikos Papakonstantinou Tasoula Touloumenidou Nikolaos Laoutaris Achilles Anagnostopoulos Klea Lamnissou Federico Caligaris-Cappio Kostas Stamatopoulos Paolo Ghia Marta Muzio Chrysoula Belessi

BACKGROUND Signaling through the B-cell receptor appears to be a major contributor to the pathogenesis of chronic lymphocytic leukemia. Toll-like receptors bridge the innate and adaptive immune responses by acting as co-stimulatory signals for B cells. The available data on the expression of Toll-like receptors in chronic lymphocytic leukemia are limited and derive from small series of patients...

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