The single stillbirth long-term intrauterine retention in dichorionic twin pregnancy is rarely reported. Also, the birth of a fetus is followed in most cases by immediate expulsion of the second twin. We hereby present an unusual case of asynchronous delivery of dichorionic twins, associating discordance for major and minor anomaly. The intrauterine death of the twin A, presenting a large sacro...

BACKGROUND Management of preterm labor by tocolysis remains an unmet medical need. Prostaglandins play a major role in regulation of uterine activity and in molecular mechanisms of human labor and parturition. There is some circumstantial evidence that prostaglandin F2alpha by action through the prostaglandin receptor subtype FP is effective in key events during labor uterine contraction, ruptu...

4-chloro-3-[(3R)-(+)-5-chloro-1-(2,4-dimethoxybenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-ethyl-N-(3-pyridylmethyl)benzamide, hydrochloride (SSR126768A), a new potent and selective, orally active oxytocin (OT) receptor antagonist was characterized in several biochemical and pharmacological models. In binding studies, SSR126768A showed nanomolar affinity for rat and human recombinant and...

OBJECTIVE To determine the efficacy of transdermal Nitroglycerine patch in idiopathic pre-term labour and foetomaternal outcome. METHODS This quasi-experimental study was conducted at the Obstetrics Unit-II of Shaikh Zayed Hospital for Women, Chandka Medical College, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, from Jan 1 to June 30, 2010. Sixtyfive pregnant women at 28-34 wee...

Purpose: We propose that using remifentanil in ex utero intrapartum treatment (EXIT) procedures reduces the need for maternal exposure to general anesthesia. Using remifentanil along with spinal anesthesia eliminates the fetal and maternal risks associated with inhalational general anesthesia, allows the mother to be awake, and obviates the need for and costs associated with general anesthesia ...

s I. Lovász Norbert, Minorics Renáta, Gáspár Róbert, Falkay György. Transzportfehérjék (ABCC8 és ABCC9) ontogenezise és a KATP csatornák szerepe a terhes patkány uterus kontraktilitásának szabályozásában. XIV. Congressus Pharmaceuticus Hungaricus; Budapest, 2009. november 13-15 (Poster). II. George Falkay, Norbert Lovasz, Eszter Ducza, Robert Gaspar. Variable expression of abcc8 and abcc9 trans...

Fire Ha Kong recipe in a concentration range of 1040 μl/ml was used to test in an in vitro uterine contraction inhibition. Contraction frequencies and amplitudes of the normal uterine of estrogen-primed non-pregnant rats were monitored. A decline in the frequencies of uterine contractions of 43.8 93.6% was detected. Addition of Fire Ha Kong at the final concentrations of 20-40 μl/ml inhibited t...

Background: Antepartum hemorrhage and placenta previa effects majority of pregnant women endangering their life both maternal and fetal. Symptomatic placenta previa are being treated with tocolytic agents. Progesterone is the most common used drug for the preservation of pregnancy and aids in the extension of pregnancy. Materials and Methods: A 80 patients were randomly assigned to two groups u...

In many cases, the management of preterm PROM will be dictated by the presence of advanced labor, intrauterine infection, placental abruption, or nonreassuring fetal testing. These patients should be delivered expeditiously, with group B streptococcus prophylaxis given where possible, and cesarean delivery reserved for routine obstetric indications. The stable patient with PPROM and documented ...

Acute pulmonary edema affects 0.08% to 1.5% of women during pregnancy and during the postpartum period, and preeclampsia/eclampsia is a major obstetric cause of acute pulmonary edema. We present a case of a 23-year-old nulliparous woman who was referred to our tertiary medical center for preterm labor and dyspnea. The patient complained of having suddenly developed respiratory distress and a de...