T he article by STRAND et al. [1] on the evaluation of the new tumour, node, metastasis (TNM) classification and staging system for lung cancer raises important questions on the validity of the classification and its therapeutic implications in clinical practice. The authors analysed a population-based series of 1,885 patients who underwent operation for lung cancer and who were registered at t...

Introduction Interdisciplinary treatment recommendations for head and neck cancer patients are mainly based on clinical staging according to the TNM classification. This study investigates value of in oral cavity (OC) oropharyngeal (OPh) carcinomas by comparing pathological stages.

The TNM pN stage based on the number of metastatic lymph nodes is an independent prognostic factor in gastric cancer. Many studies have highlighted the phenomenon of stage migration and problems in comparing groups of patients with different numbers of total lymph nodes harvested within TNM staging. The current version of UICC/AJCC and JGCA TNM classifications postulates a minimal number of 16 ...

Hypothesis / aims of study Tibial neuromodulation (TNM) is a clinically used therapy for patients with refractory, idiopathic overactive bladder [1]. TNM is currently delivered percutaneous using a needle electrode. Therapy sessions are commonly 30 minutes of stimulation once per week. There are questions regarding how often therapy should be delivered as well as optimal clinical and patient sc...

We investigate the expression and localization of the tumor suppressor protein pVHL as well as the oncoprotein Aurora A kinase in kidney cancer. Both Aurora A kinase and pVHL protein status were evaluated using immunohistochemistry. The Aurora A expression is correlated with the Fuhrman grade and the TNM stage, while the pVHL expression is correlated with the capsule rupture and the TNM stage. ...

Since January of 2010, the seventh edition of UICC tumor node metastasis (TNM) Classification, which has recently been revised, has been applied to almost all cases of malignant tumors. Compared to previous editions, the merits and demerits of the current revisions were analyzed. Many revisions have been made for criteria for the classification of lymph nodes. In particular, all the cases in wh...