BACKGROUND Tissues respond to injury by releasing acute phase reaction (APR) proteins which regulate inflammation and angiogenesis. Among the genes upregulated in wounded tissues are tumor necrosis factor-alpha (TNFα) and the acute phase reactant orosomucoid-1 (ORM1). ORM1 has been shown to modulate the response of immune cells to TNFα, but its role on injury- and TNFα-induced angiogenesis has ...

INTRODUCTION In this study, we tested the ability of small molecule inhibitors of WNT/β-catenin signaling to block interleukin 1β (IL-1β)- and tumor necrosis factor α (TNFα)-induced cartilage degradation. Proinflammatory cytokines such as IL-1β and TNFα are potent inducers of cartilage degradation by upregulating matrix metalloproteinase (MMP) expression and activity. Because WNT/β-catenin sign...

abstract objectives: tumour necrosis factor α (tnfα) and lymphotoxin α (ltα) have been implicated in the pathogenesis of lymphoproliferative disorders. patients with b-cell non-hodgkin’s lymphoma (nhl) often have high serum levels of tnf which may be associated with a poor outcome. tnfα and ltα polymorphisms are known to influence expression of these cytokines and may explain the variable respo...

Background/Aim: Alopecia areata (AA), which is characterized by hair loss, an inflammatory autoimmune disease. Tumor necrosis factor-alpha (TNFα) a potent proinflammatory cytokine that has highly significant role in and immune responses. The aim of this study to evaluate whether there relationship between TNFα -238 G/A gene polymorphism AA the Turkish population. Methods: In case-control study,...

Tumor necrosis factor alpha (TNFα) plays diverse roles in liver damage and hepatocarcinogenesis with its multipotent bioactivity. However, the influence of TNFα on protein expression of hepatocellular carcinoma (HCC) is incompletely understood. Therefore, we aimed to investigate the differential protein expression of HCC in response to TNFα stimulus. We observed that HepG2 cell revealed a highe...

Angiotensin II (Ang-II) exerts inflammatory activity and is involved in different cardiovascular disorders. This study has evaluated the involvement of TNFα in the leukocyte accumulation elicited by Ang-II. Ang-II (1 nmol/L, i.p., in rats) induced TNFα release at 1h followed by neutrophil and mononuclear cell recruitment. The administration of an anti-rat TNFα antiserum had no effect on Ang-II-...

TNFα has been implicated in the pathogenesis of various inflammatory diseases. Different strategies to inhibit TNFα in patients with sepsis and chronic inflammatory conditions have shown contrasting outcomes. Although TNFα inhibitors are widely used in clinical practice, the impact of TNFα antagonism on white blood cell gene expression profiles during acute inflammation in humans in vivo has no...

Chronic inflammation-promoted metastasis has been considered as a major challenge in cancer therapy. Pro-inflammatory cytokine TNFα can induce cancer invasion and metastasis associated with epithelial-mesenchymal transition (EMT). However, the underlying mechanisms are not entirely clear. In this study, we showed that TNFα induces EMT in human HCT116 cells and thereby promotes colorectal cancer...

BACKGROUND Atherosclerosis may be stimulated by the increased presence of insulin and tumor necrosis-factor-α (TNFα) with subsequent expression of vascular cell adhesion molecule-1 (VCAM-1). We hypothesized that extracellular signal-regulated kinase-5 (ERK5) plays an important role in insulin and TNFα-stimulated total and cell surface VCAM-1 expression. METHODS Rat aorta vascular endothelial ...