Alteration of androgen receptor function due to hormonally active compounds in the environment, may be responsible for impaired reproductive function in aquatic wildlife. Based on human prostate carcinoma 22RV1 cells, a cell culture expression system was established to test effects of putative androgenic/antiandrogenic compounds on endogenous gene expression. 22RV1 cells were shown to express h...

EGFR or ERBB2 contributes to prostate cancer (PCa) progression by activating the androgen receptor (AR) in hormone-poor conditions. Here, we investigated the mechanisms by which androgens regulate EGFR and ERBB2 expression in PCa cells. In steroid-depleted medium (SDM), EGFR protein was less abundant in androgen-sensitive LNCaP than in androgen ablation-resistant 22Rv1 cells, whereas transcript...

Objetivo: Avaliar os impactos gerais da infecção pelo SARS-CoV-2 na saúde reprodutiva feminina assim como nos procedimentos de reprodução assistida. Revisão bibliográfica: O surgiu em dezembro 2019 e se espalhou rapidamente mundo. vírus adentra a célula–alvo ligando-se enzima conversão angiotensina (ACE) 2, serina protease transmembranar 2 (TMPRSS2) 4 (TMPRSS4) proteína transmembrana Basigin (B...

Infection of certain influenza viruses is triggered when its HA cleaved by host cell proteases such as proprotein convertases and type II transmembrane serine (TTSP). with a monobasic motif trypsin-like proteases, including TMPRSS2 HAT, whereas the multibasic found in high pathogenicity avian furin, PC5/6, or MSPL. MSPL belongs to TMPRSS family preferentially cleaves [R/K]-K-K-R↓ sequences. Her...

Background Periodontitis links extensively to various non-communicable diseases such as diabetes and cardiovascular disease most recently COVID-19 complications. Two important proteins in humans, ACE2 TMPRSS2, have been associated with health problems coronavirus infection. This study was investigate the soluble TMPRSS2 saliva serum well their association periodontal status systemic conditions....

SARS-CoV-2 (2019-nCoV) is the pathogenic coronavirus responsible for global pandemic of COVID-19 disease. The Spike (S) protein attaches to host lung epithelial cells through cell surface receptor ACE2, a process dependent on proteases including TMPRSS2. Here, we identified small molecules that can reduce expression TMPRSS2 using 2,700 FDA-approved or current clinical trial compounds. Among the...

mutation or TMPRSS2‐ERG fusions induced proliferation and invasion in prostate cancer cells. This study along with a recently published similar report provides two previously unrecognized mechanisms for the upregulation of ERG proteins frequently observed in prostate cancers. These findings generate great enthusiasm for the development of targeted therapeutic strategies designed to eliminate ER...