A new compound granular premix of amoxicillin (20% w/w dry mass)/apramycin (5% w/w dry mass) was developed, and its pharmacokinetics and relative bioavailability were determined in pigs following oral administration following a cross-over study design. The pharmacokinetic parameters of amoxicillin (t1/2λ = 6.43 ± 4.85h, Cmax = 3.2 ± 1.35 μg·mL-1, Tmax = 1.92 ± 0.58, AUCINF = 8.98 ± 2.11 h·μg·mL...

The magnetic behaviour of 5 to 11 nm magnetite (Fe3O4) nanoparticles (NPs) was measured at various temperatures (Ts) from 20 to 400 K. The particles were fabricated via thermal decomposition of an iron precursor, and involved a coating of the particles with oleic acid. The particle size distribution was analysed by XRD measurements and TEM imaging. Magnetization loops, measured at various Ts, i...

Abstract Background An area of current study concerns analysis the possible adaptation population to heat, based on temporal evolution minimum mortality temperature (MMT). It is important know how threshold temperatures (Tthreshold) due these provide basis for activation public health prevention plans against high temperatures. The objective this was analyze produced in different Spanish region...

The pharmacokinetics and penetration into a cantharidine-induced inflammatory exudate of meropenem was studied in six volunteers following a single 1-g intravenous dose. Concentrations in plasma, urine, and the inflammatory exudate were determined by a microbiological assay. The mean elimination half-life of meropenem in plasma was 1.1 h, with the concentration in plasma declining from a mean o...

Trends in seasonal mean values of maximum and minimum temperature are analysed the Spanish mainland from new MOTEDAS_century database. This data set has been developed combining digitalized archives Meteorological Agency (AEMET) with information retrieved Annual Books published by former dating back to 1916, covers period 1916–2015. In all four seasons, (Tmax) (Tmin) increased. The raising occu...

Having an extreme topography and heterogeneous climate, the Upper Indus Basin (UIB) is more likely to be affected by climate change it a crucial area for climatological studies. Based on monthly minimum temperature (Tmin), maximum (Tmax) precipitation from nine meteorological stations, spatiotemporal variability of were analyzed monthly, seasonal, annual scales. Results show widespread signific...

Geospatial methods were used to study the associations of the environmental thermal-hydrological regime with leprosy prevalence in the Oromia and Amhara regions of Ethiopia. Prediction models were developed that indicated leprosy prevalence was related to: (i) long-term normal climate grid data on temperature and moisture balance (rain/potential evapo-transpiration); (ii) satellite surveillance...

This study aimed to establish a standard dose and sample collection time for (13)C phenylalanine and (13)C-Dipeptide breath test in horses. To evaluate dose-dependent effects, healthy horses received 2.5 mg/kg, 5 mg/kg, and 10 mg/kg (13)C phenylalanine dissolved in 1 ml/kg distilled water and 1.25 mg/kg, 2.5 mg/kg, and 5 mg/kg (13)C dipeptide dissolved in 2 ml/ kg distilled water. Tmax was obse...

In the presented study, Ni impurity is used to probe pseudogap and superconducting gap in underdoped cuprate La1.85Sr0.15CuO4. The longitudinal magnetoresistance measurements reveal presence of local maximum at same temperature Tmax, below which zero-field resistivity parallel-resistor model deviates from its T2-dependence. Tracking systematic evolution with content y allows equating Tmax T*. r...

The pharmacokinetics of five dose levels of lomefloxacin (100, 200, 400, 600, and 800 mg) were examined in a single-dose, double-blind, placebo-controlled study involving 40 subjects. There were eight subjects in each group: five received active drug and three received placebo; each subject was given only one dose. All subjects completed the study, and lomefloxacin was well tolerated at all dos...