Tumor lysis syndrome (TLS) is a potentially life-threating complication of tumors or chemotherapy treatment. TLS commonly occurs in hematological malignancies, but it is very rare in patients with a solid tumor. In cases of solid tumors, TLS usually occurs spontaneously and after the initiation of anticancer therapy, and it has a high mortality rate. We present the novel case of a 62-year-old w...

DNA damage tolerance pathways allow cells to duplicate their genomes despite the presence of replication blocking lesions. Cells possess two major tolerance strategies, namely translesion synthesis (TLS) and homology directed gap repair (HDGR). TLS pathways involve specialized DNA polymerases that are able to synthesize past DNA lesions with an intrinsic risk of causing point mutations. In cont...

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Currently a new wave flume for hydraulic experiments near to prototype scale is under construction at Deltares. In the flume, modern measurement equipment will be installed. One of the potential sensor techniques is Terrestrial Laser Scanner (TLS) based range measurements of water waves. TLS range measurements are a very fast and accurate method for solid surfaces, providing temporal and spatia...

Amorphous solids, as well as many disordered lattices, display remarkable universality in their low temperature acoustic properties. This universality is attributed to the attenuation of phonons by tunneling two-level systems (TLSs), facilitated by the interaction of the TLSs with the phonon field. TLS-phonon interaction also mediates effective TLS-TLS interactions, which dictates the existence...

Long-term synaptic change in the cortex and the hippocampus is believed to require the highly localized delivery and translation of mRNAs in the dendritic shafts and spines. The molecular interactions that underlie local signalling between synapses and mRNAs are still largely undefined. After purification from total brain extracts, the NMDA receptor is known to be associated with numerous prote...

DNA lesions, induced by genotoxic compounds, block the processive replication fork but can be bypassed by specialized translesion synthesis (TLS) DNA polymerases (Pols). TLS safeguards the completion of replication, albeit at the expense of nucleotide substitution mutations. We studied the in vivo role of individual TLS Pols in cellular responses to benzo[a]pyrene diolepoxide (BPDE), a polycycl...

While Chip Multiprocessors (CMP) with Thread-Level Speculation (TLS) have become the subject of intense research, processor designers in industry have reservations about their practical implementation. An often cited complaint is that TLS is too energy-inefficient to compete against conventional superscalars. This paper challenges the commonly-held view that TLS is energy inefficient. We identi...

When a replicative DNA polymerase stalls upon encountering a lesion on the template strand, it is relieved by other low-processivity polymerase(s), which insert nucleotide(s) opposite the lesion, extend by a few nucleotides, and dissociate from the 3'-OH. The replicative polymerase then resumes DNA synthesis. This process, termed translesion replication (TLS) or replicative bypass, may involve ...

This document specifies how to establish secure connection-oriented media transport sessions over the Transport Layer Security (TLS) protocol using the Session Description Protocol (SDP). It defines a new SDP protocol identifier, ’TCP/TLS’. It also defines the syntax and semantics for an SDP ’fingerprint’ attribute that identifies the certificate that will be presented for the TLS session. This...