TLS (translation/libration/screw) models describe rigid-body vibrational motions of arbitrary objects. A single-group TLS model can be used to approximate the vibration of an entire protein molecule within a crystal lattice. More complex TLS models are broadly applicable to describing inter-domain and other internal vibrational modes of proteins. Such models can be derived and refined from crys...

As mobile applications become more pervasive, they provide us with a variety of online services that range from social networking to banking and credit card management. Since many of these services involve communicating and handling of private user information – and also due to increasing security demands from users – the use of TLS connections has become a necessity for today’s mobile applicat...

The main purpose of this paper is to present an overview of the progress of a modeling technique which is known as Total Least Squares (TLS) in computational mathematics and engineering, and as Errors-InVariables (EIV) modeling or orthogonal regression in the statistical community. The basic concepts of TLS and EIV modeling are presented. In particular, it is shown how the seemingly different l...

Thread-Level Speculation (TLS) allows potentially dependent threads to execute in parallel, by postponing the detection and verification of inter-thread data dependences until runtime. Although TLS greatly simplifies automatic parallelization, only moderate performance improvements have been achieved for general-purpose applications. Thus adequate compiler techniques must be developed to fully ...

INTRODUCTION FUS/TLS is an RNA-binding protein whose genetic mutations or pathological inclusions are associated with neurological diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration, and essential tremor (ET). It is unclear whether their pathogenesis is mediated by gain or loss of function of FUS/TLS. RESULTS Here, we established outbred FUS/TLS knockout...

Translesion DNA synthesis (TLS) is a mode of DNA damage tolerance which plays an important role in genome mutagenesis and chromatin integrity maintenance. Proliferating cell nuclear antigen (PCNA) monoubiquitylation is one of the key factors for TLS pathway choice. So far, it remains unclear how the TLS pathway is elaborately regulated. Here, we report that TLS polymerase REV1 can promote PCNA ...

In this paper, we analyse the Transport Layer Security (TLS) protocol within the strand spaces setting. In [BL03] Broadfoot and Lowe suggested an abstraction of TLS. The abstraction models the security services that appear to be provided by the protocol to the high-level security layers. The outcome of our analysis provides a formalisation of the security services provided by TLS and proves tha...

because of fluctuation in leg tension, pitch motion is very effective fatigue and life safety of leg elements in tension leg structures (tlss). in this paper an exact solution for pitch vibration of a tls interacting with ocean wave is presented. the legs of tlp are considered as elastic springs. the flow is assumed to be irrotational and single-valued velocity potentials are defined. the effec...

Purpose: Flavopiridol, the first clinically evaluated cyclin-dependent kinase inhibitor, shows activity in patients with refractory chronic lymphocytic leukemia, but prevalent and unpredictable tumor lysis syndrome (TLS) presents a major barrier to its broad clinical use. The purpose of this study was to investigate the relationships between pretreatment risk factors, drug pharmacokinetics, and...

Terrestrial laser scanning (TLS) and unmanned aerial vehicles (UAVs) equipped with digital cameras have attracted much attention from the forestry community as potential tools for forest inventories and forest monitoring. This research fills a knowledge gap about the viability and dissimilarities of using these technologies for measuring the top of canopy structure in tropical forests. In an em...