نتایج جستجو برای: tlr algorithm
تعداد نتایج: 762507 فیلتر نتایج به سال:
The Gal/GalNAc lectin (Gal-lectin) of Entamoeba histolytica is a surface molecule involved in parasite adherence to host cells and is the most promising subunit vaccine candidate against amoebiasis. As macrophages are the major effector cells in host defense against amoebas, we studied the molecular mechanisms by which Gal-lectin activates macrophage. Microarray analysis showed that Gal-lectin ...
Acute kidney injury (AKI) is one of the most important complications in hospitalized patients and its pathomechanisms are not completely elucidated. We hypothesize that signaling via toll-like receptor (TLR)-3, a receptor that is activated upon binding of double-stranded nucleotides, might play a crucial role in the pathogenesis of AKI following ischemia and reperfusion (IR). Male adult C57Bl6 ...
OBJECTIVE This study aimed to compare 1-year clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion (CTO) lesions. METHODS A total of 2865 patients (age 62.82±10.64 years; 74.0% men) undergoing percutaneous coronary intervention for CTO were analyzed. The patients were classified as diabetic (n=977) or nondiabetic (n=1888). One-year clinical outcomes were compared...
Although post-ischemic stroke process is essential for the repair of infarcted area, excessive inflammation during this can induce tissue damage. Damage-associated molecular patterns (DAMPs) released from injured cells in early phase ischemic cytokine and chemokine production by activating microglia, thereby facilitating neutrophil lymphocyte infiltration. However, inhibition neutrophils, lymph...
BackgroundCoronary calcification impairs stent delivery and optimal expansion, a significant predictor of subsequent thrombosis restenosis. Current calcium ablative technologies may be limited by guidewire bias periprocedural complications. Intravascular lithotripsy (IVL) delivers acoustic pressure waves to modify calcium, enhance vessel compliance, optimize deployment. The Disrupt CAD III stud...
Abstract Objectives: The mechanosensitive Ca 2+ion channels, Piezo1, converts the mechanical stimulus into cell signals in a variety of immune cells. However, pathophysiological property Piezo1 oral polymicrobial infectious disease periodontitis is largely unknown. This study investigated role inflammatory and phagocytic reactions by RAW264.7 macrophages response to exposures periodontal pathog...
Background: The pathogenesis of migraine involves immune-mediated mechanisms in the vascular endothelium. Toll like receptor 4 (TLR-4) is a signaling receptor of innate immunity which plays a role in various neuropathologies related to neuron inflammation. Objective: This case/control study is aimed to investigate whether TLR- 4 896A/G variation is related to migraine headaches in an Iranian po...
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